[HTML][HTML] Does genetic predisposition contribute to the exacerbation of COVID-19 symptoms in individuals with comorbidities and explain the huge mortality disparity …

N Yamamoto, R Yamamoto, Y Ariumi… - International Journal of …, 2021 - mdpi.com
The elderly and patients with several comorbidities experience more severe cases of
coronavirus disease 2019 (COVID-19) than healthy patients without underlying medical …

Global distribution of ACE1 (rs4646994) and ACE2 (rs2285666) polymorphisms associated with COVID-19: A systematic review and meta-analysis

M Keikha, M Karbalaei - Microbial Pathogenesis, 2022 - Elsevier
Background Recent studies emphasize the significant impact of the renin-angiotensin
aldosterone system (RAAS) as a risk factor associated with severe acute respiratory …

[HTML][HTML] ACE gene variants rise the risk of severe COVID-19 in patients with hypertension, dyslipidemia or diabetes: a Spanish pilot study

M Iniguez, P Perez-Matute… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 19 (COVID-19) caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection continues to scale and threaten human health and …

Angiotensin-converting enzyme 1 and voltage-gated potassium channel-interacting protein 4 gene polymorphisms in COVID-19 patients from east of Iran

H Abbaszadeh, F Mohammadi… - Clinica Chimica …, 2022 - Elsevier
Abstract Background Coronavirus disease 2019 (COVID-19), the infectious respiratory
disease caused by a newly discovered pathogen (severe acute respiratory syndrome …

Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID‐19: A case study

S Karakaş Çelik, G Çakmak Genç… - Journal of Medical …, 2021 - Wiley Online Library
Coronavirus disease 2019 (COVID‐19) is an infectious disease, and the reason behind the
currently ongoing pandemic, caused by severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] Association investigations between ACE1 and ACE2 polymorphisms and severity of COVID-19 disease

M Najafi, MR Mahdavi - Molecular Genetics and Genomics, 2023 - Springer
Due to the unique affinity of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) to the angiotensin-converting enzyme 2 (ACE2) receptor in patients, the foremost …

Association of ACE1 I/D rs1799752 and ACE2 rs2285666 polymorphisms with the infection and severity of COVID‐19: A meta‐analysis

MA Aziz, MS Islam - Molecular Genetics & Genomic Medicine, 2022 - Wiley Online Library
Abstract Background ACE1 I/D rs1799752 and ACE2 rs2285666 genetic polymorphisms
could play a critical role in altering the clinical outcomes of SARS‐CoV‐2. The findings of …

Distribution of the ACE1 D Allele in the Bosnian–Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19

M Cenanovic, S Dogan, A Asic, L Besic… - Genetic Testing and …, 2021 - liebertpub.com
Background: The human angiotensin I converting enzyme 1 (ACE1) gene insertion/deletion
(I/D) polymorphism is classified based on the presence or absence of a 287 bp Alu …

[HTML][HTML] Angiotensin-converting enzyme 2 SNPs as common genetic loci and optimal early identification genetic markers for COVID-19

Y Ma, Q Li, J Chen, S Liu, S Liu, X He, Y Ling, J Zheng… - Pathogens, 2022 - mdpi.com
Background: Angiotensin-converting enzyme 2 (ACE2) is implicated as a host cell receptor
that causes infection in the pathogenesis of coronavirus disease 2019 (COVID-19), and its …

[PDF][PDF] Angiotensin-Converting Enzyme Receptor Genotype and its Activity Level as Potential Predictors of the Severity COVID-19 among Iraqi Patients.

SH Kamel, FJ Al-Tu'ma, RM Al-Saegh - Journal of Contemporary Medical …, 2021 - iasj.net
Objectives: The purpose of this study is to determine whether the angiotensin-converting
enzyme activity and various biomarkers are used to investigate the severity of Covid-19 and …