Targeting the tick protective antigen subolesin reduces vector infestations and pathogen infection by Anaplasma marginale and Babesia bigemina

O Merino, C Almazán, M Canales, M Villar… - Vaccine, 2011 - Elsevier
The ultimate goal of vector vaccines is the control of vector infestations while reducing
pathogen infection and transmission to protect against the many diseases caused by vector …

Control of Rhipicephalus (Boophilus) microplus infestations by the combination of subolesin vaccination and tick autocidal control after subolesin gene knockdown in …

O Merino, C Almazán, M Canales, M Villar… - Vaccine, 2011 - Elsevier
Tick subolesin was shown in immunization trials using the recombinant protein to protect
hosts against tick infestations. In this study, we demonstrated that subolesin vaccination and …

Differential Expression of the Tick Protective Antigen Subolesin in Anaplasma marginale‐ and A. phagocytophilum‐infected Host Cells

J De La Fuente, EF Blouin… - Annals of the New …, 2008 - Wiley Online Library
Subolesin was recently shown in vaccine and RNA interference (RNAi) studies to protect
against tick infestations and to affect tick feeding, reproduction, and development as well as …

Reduction of tick infections with Anaplasma marginale and A. phagocytophilum by targeting the tick protective antigen subolesin

J de la Fuente, C Almazán, EF Blouin, V Naranjo… - Parasitology …, 2006 - Springer
Subolesin was recently shown by both gene silencing and immunization with the
recombinant protein to protect against tick infestations, and to cause reduced tick survival …

Vaccination with proteins involved in tick–pathogen interactions reduces vector infestations and pathogen infection

O Merino, S Antunes, J Mosqueda, JA Moreno-Cid… - Vaccine, 2013 - Elsevier
Tick-borne pathogens cause diseases that greatly impact animal health and production
worldwide. The ultimate goal of tick vaccines is to protect against tick-borne diseases …

[HTML][HTML] Control of tick infestations and pathogen prevalence in cattle and sheep farms vaccinated with the recombinant Subolesin-Major Surface Protein 1a chimeric …

A Torina, JA Moreno-Cid, V Blanda… - Parasites & vectors, 2014 - Springer
Background Despite the use of chemical acaricides, tick infestations continue to affect
animal health and production worldwide. Tick vaccines have been proposed as a cost …

[HTML][HTML] Subolesin vaccination inhibits blood feeding and reproduction of Haemaphysalis longicornis in rabbits

SH Lee, J Li, PFA Moumouni, K Okado, W Zheng… - Parasites & vectors, 2020 - Springer
Background Ticks can transmit numerous tick-borne pathogens and cause a huge economic
loss to the livestock industry. Tick vaccines can contribute to the prevention of tick-borne …

[HTML][HTML] Subolesin expression in response to pathogen infection in ticks

Z Zivkovic, A Torina, R Mitra, A Alongi, S Scimeca… - Bmc Immunology, 2010 - Springer
Abstract Background Ticks (Acari: Ixodidae) are vectors of pathogens worldwide that cause
diseases in humans and animals. Ticks and pathogens have co-evolved molecular …

Subolesin/akirin orthologs from Ornithodoros spp. soft ticks: cloning, RNAi gene silencing and protective effect of the recombinant proteins

R Manzano-Román, V Díaz-Martín, A Oleaga… - Veterinary …, 2012 - Elsevier
Subolesin/akirin is a well characterized protective antigen highly conserved across vector
species and thus potentially useful for the development of a broad-spectrum vaccine for the …

Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission

J de la Fuente, JA Moreno-Cid, M Canales, M Villar… - Veterinary …, 2011 - Elsevier
Diseases caused by arthropod-borne pathogens greatly impact on human and animal
health. Recent research has provided evidence that tick protective antigens can be used for …