Emerging EPO and EPO receptor regulators and signal transducers

D Kuhrt, DM Wojchowski - Blood, The Journal of the American …, 2015 - ashpublications.org
As essential mediators of red cell production, erythropoietin (EPO) and its cell surface
receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined …

Erythropoietin-dependent erythropoiesis: New insights and questions

DM Wojchowski, MP Menon, P Sathyanarayana… - Blood Cells, Molecules …, 2006 - Elsevier
Committed erythroid progenitor cells require exposure to erythropoietin (Epo) for their
survival and for their quantitatively regulated transition to red blood cells. With regard to Epo …

Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration

HE Broxmeyer - Journal of Experimental Medicine, 2013 - rupress.org
Erythropoietin (EPO), a humoral regulator of erythropoiesis and replacement therapy for
selected red blood cell disorders in EPO-deficient patients, has been implicated in a wide …

Erythropoietin receptor response circuits

DM Wojchowski, P Sathyanarayana… - Current opinion in …, 2010 - journals.lww.com
Summary As Current Opinion, this monograph seeks to summarize, and provoke, new
EPO/EPOR action concepts. Specific problems addressed include: beyond (and before) …

Turning cells red: signal transduction mediated by erythropoietin

TD Richmond, M Chohan, DL Barber - Trends in cell biology, 2005 - cell.com
Erythropoietin (EPO) is the crucial cytokine regulator of red blood-cell production. Since the
discovery of EPO in 1985 and the isolation of its cognate receptor four years later, there has …

[HTML][HTML] Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise

M Brines, A Cerami - Kidney international, 2006 - Elsevier
A greatly expanded understanding of the biology of endogenous erythropoietin (EPO) has
emerged since the early 1990s. Originally viewed as the renal hormone dedicated to …

Survival and proliferative roles of erythropoietin beyond the erythroid lineage

CT Noguchi, L Wang, HM Rogers, R Teng… - Expert reviews in …, 2008 - cambridge.org
Since the isolation and purification of erythropoietin (EPO) in 1977, the essential role of EPO
for mature red blood cell production has been well established. The cloning of the EPO gene …

Core erythropoietin receptor signals for late erythroblast development

MP Menon, J Fang, DM Wojchowski - Blood, 2006 - ashpublications.org
Critical signals for erythroblast formation are transduced by activated, tyrosine-
phosphorylated erythropoietin receptor (EpoR) complexes. Nonetheless, steady-state …

Targeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis

N Rainville, E Jachimowicz… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Recombinant human erythropoietin (rhEPO) is a first-line therapeutic for the
anemia of chronic kidney disease, cancer chemotherapy, AIDS (Zidovudine therapy), and …

[HTML][HTML] Erythropoietin regulation of red blood cell production: From bench to bedside and back

SV Bhoopalan, LJ Huang, MJ Weiss - F1000Research, 2020 - ncbi.nlm.nih.gov
More than 50 years of efforts to identify the major cytokine responsible for red blood cell
(RBC) production (erythropoiesis) led to the identification of erythropoietin (EPO) in 1977 …