Committed erythroid progenitor cells require exposure to erythropoietin (Epo) for their survival and for their quantitatively regulated transition to red blood cells. With regard to Epo …
HE Broxmeyer - Journal of Experimental Medicine, 2013 - rupress.org
Erythropoietin (EPO), a humoral regulator of erythropoiesis and replacement therapy for selected red blood cell disorders in EPO-deficient patients, has been implicated in a wide …
DM Wojchowski, P Sathyanarayana… - Current opinion in …, 2010 - journals.lww.com
Summary As Current Opinion, this monograph seeks to summarize, and provoke, new EPO/EPOR action concepts. Specific problems addressed include: beyond (and before) …
TD Richmond, M Chohan, DL Barber - Trends in cell biology, 2005 - cell.com
Erythropoietin (EPO) is the crucial cytokine regulator of red blood-cell production. Since the discovery of EPO in 1985 and the isolation of its cognate receptor four years later, there has …
M Brines, A Cerami - Kidney international, 2006 - Elsevier
A greatly expanded understanding of the biology of endogenous erythropoietin (EPO) has emerged since the early 1990s. Originally viewed as the renal hormone dedicated to …
CT Noguchi, L Wang, HM Rogers, R Teng… - Expert reviews in …, 2008 - cambridge.org
Since the isolation and purification of erythropoietin (EPO) in 1977, the essential role of EPO for mature red blood cell production has been well established. The cloning of the EPO gene …
N Rainville, E Jachimowicz… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Recombinant human erythropoietin (rhEPO) is a first-line therapeutic for the anemia of chronic kidney disease, cancer chemotherapy, AIDS (Zidovudine therapy), and …
More than 50 years of efforts to identify the major cytokine responsible for red blood cell (RBC) production (erythropoiesis) led to the identification of erythropoietin (EPO) in 1977 …