Dietary administration of sodium arsenite to rats: relations between dose and urinary concentrations of methylated and thio-metabolites and effects on the rat urinary …

S Suzuki, LL Arnold, KL Pennington, B Chen… - Toxicology and Applied …, 2010 - Elsevier
Based on epidemiological data, chronic exposure to high levels of inorganic arsenic in
drinking water is carcinogenic to humans, inducing skin, urinary bladder and lung tumors. In …

Cytotoxicity of combinations of arsenicals on rat urinary bladder urothelial cells in vitro

MG Nascimento, S Suzuki, M Wei, A Tiwari, LL Arnold… - Toxicology, 2008 - Elsevier
Based on epidemiological data, chronic exposure to high levels of inorganic arsenic in the
drinking water is carcinogenic to the urinary bladder of humans. The highly reactive trivalent …

Urothelial cytotoxicity and regeneration induced by dimethylarsinic acid in rats

SM Cohen, S Yamamoto, M Cano… - Toxicological …, 2001 - academic.oup.com
Inorganic arsenic is a known human carcinogen of the skin and respiratory tract.
Epidemiologic evidence indicates that it is also carcinogenic to the urinary bladder and other …

Effects of inorganic arsenic on the rat and mouse urinary bladder

S Suzuki, LL Arnold, T Ohnishi… - Toxicological …, 2008 - academic.oup.com
Inorganic arsenic (arsenate and arsenite) is a known human carcinogen, inducing tumors of
the skin, urinary bladder, and lung. Understanding the mechanism of inorganic arsenic …

A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response

J Shen, H Wanibuchi, MP Waalkes, EI Salim… - Toxicology and applied …, 2006 - Elsevier
Epidemiological studies indicated that human arsenic exposure can induce urinary bladder
cancer. Methylation of inorganic arsenic can generate more reactive and toxic organic …

Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following subchronic exposure to arsenate in drinking …

EM Kenyon, MF Hughes, BM Adair, JH Highfill… - Toxicology and applied …, 2008 - Elsevier
The relationship of exposure and tissue concentration of parent chemical and metabolites
over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite (s) …

Time course of urothelial changes in rats and mice orally administered arsenite

LL Arnold, S Suzuki, M Yokohira… - Toxicologic …, 2014 - journals.sagepub.com
Inorganic arsenic (arsenite and arsenate) at high exposures is a known human carcinogen,
inducing tumors of the urinary bladder, skin, and lungs. In two experiments, we examined …

Effect of dietary treatment with dimethylarsinous acid (DMAIII) on the urinary bladder epithelium of arsenic (+ 3 oxidation state) methyltransferase (As3mt) knockout …

PR Dodmane, LL Arnold, KL Pennington, DJ Thomas… - Toxicology, 2013 - Elsevier
Chronic exposure to inorganic arsenic (iAs) is carcinogenic to the human urinary bladder. It
produces urothelial cytotoxicity and proliferation in rats and mice. DMAV, a major methylated …

Tissue distribution and urinary excretion of dimethylated arsenic and its metabolites in dimethylarsinic acid-or arsenate-treated rats

BM Adair, T Moore, SD Conklin, JT Creed… - Toxicology and applied …, 2007 - Elsevier
Adult female Fisher 344 rats received drinking water containing 0, 4, 40, 100, or 200 parts
per million of dimethylarsinic acid or 100 parts per million of arsenate for 14 days. Urine was …

Arsenic and urinary bladder cell proliferation

MI Luster, PP Simeonova - Toxicology and applied pharmacology, 2004 - Elsevier
Epidemiologic studies have demonstrated that a close association exists between the
elevated levels of arsenic in drinking water and the incidence of certain cancers, including …