[HTML][HTML] Pulmonary embolism and 529 human blood metabolites: genetic correlation and two-sample Mendelian randomization study
R Feng, M Lu, J Xu, F Zhang, M Yang, P Luo, K Xu… - BMC genomic data, 2022 - Springer
Background The incidence of pulmonary embolism complications in the literature ranges
from 10 to 50%, with a 0.5–10% risk of fatal pulmonary embolism. However, the biological …
from 10 to 50%, with a 0.5–10% risk of fatal pulmonary embolism. However, the biological …
[HTML][HTML] Genome-wide association analyses identified novel susceptibility loci for pulmonary embolism among Han Chinese population
Background A large proportion of pulmonary embolism (PE) heritability remains
unexplained, particularly among the East Asian (EAS) population. Our study aims to expand …
unexplained, particularly among the East Asian (EAS) population. Our study aims to expand …
A genome‐wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium
W Tang, M Teichert, DI Chasman, JA Heit… - Genetic …, 2013 - Wiley Online Library
Venous thromboembolism (VTE) is a common, heritable disease resulting in high rates of
hospitalization and mortality. Yet few associations between VTE and genetic variants, all in …
hospitalization and mortality. Yet few associations between VTE and genetic variants, all in …
[HTML][HTML] Prediction of primary venous thromboembolism based on clinical and genetic factors within the UK Biobank
DA Kolin, S Kulm, O Elemento - Scientific reports, 2021 - nature.com
Both clinical and genetic factors drive the risk of venous thromboembolism. However,
whether clinically recorded risk factors and genetic variants can be combined into a clinically …
whether clinically recorded risk factors and genetic variants can be combined into a clinically …
Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism
We report a genome-wide association study of venous thromboembolism (VTE)
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …
incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 …
Cross-ancestry investigation of venous thromboembolism genomic predictors
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …
environmental and genetic determinants. Recent VTE genome-wide association studies …
Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease
Venous thromboembolism is a significant cause of mortality, yet its genetic determinants are
incompletely defined. We performed a discovery genome-wide association study in the …
incompletely defined. We performed a discovery genome-wide association study in the …
Novel genetic predictors of venous thromboembolism risk in African Americans
W Hernandez, ER Gamazon… - Blood, The Journal …, 2016 - ashpublications.org
Venous thromboembolism (VTE) is the third most common life-threatening cardiovascular
condition in the United States, with African Americans (AAs) having a 30% to 60% higher …
condition in the United States, with African Americans (AAs) having a 30% to 60% higher …
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …
advance our understanding of the biology contributing to VTE, we conducted a genome …
[HTML][HTML] Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development
Genome-wide association studies (GWAS) have identified numerous risk loci for venous
thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We …
thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We …