Among the numerous pain control mechanisms that have been proposed, those acting at the
spinal cord have been broadly studied, but little is known about how neuropeptides …

A hypothalamic oxytocinergic-descending pathway that reaches the dorsal horn of the spinal
cord has been well documented and recently related to states of pain and analgesia. In …

Background Growing evidence in the literature shows that oxytocin (OT) has a strong spinal
anti-nociceptive action. Oxytocinergic axons originating from a subpopulation of …

Oxytocin is a hypothalamic neuropeptide involved in the inhibition of nociception
transmission at spinal dorsal horn (SDH) level (the first station where the incoming …

Background: Recent evidence suggests that oxytocin (OT), secreted in the superficial spinal
cord dorsal horn by descending axons of paraventricular hypothalamic nucleus (PVN) …

Oxytocin can influence various spinal functions. However, little is known about the spinal
neuronal networks responsible for oxytocin effects. The aim of this study was to localize and …

In recent years, oxytocin has been implicated in a wide diversity of functions. The role of
oxytocin in analgesia and pain modulation represents an important new function of an …

Oxytocin properties have been studied in different experimental models in order to obtain
evidence for its analgesic properties. The analgesic effect of an oxytocinergic pathway …

The search for new ligands to treat neuropathic pain remains a challenge. Recently,
oxytocin has emerged as an interesting molecule modulating nociception at central and …

Oxytocin (OT) has emerged as a mediator of endogenous analgesia in behavioral and
electrophysiological experiments. In fact, OT receptors (OTRs) in the spinal dorsal horn …