Natural product compounds in alpinia officinarum and ginger are potent SARS-CoV-2 papain-like protease inhibitors

D Goswami, M Kumar, SK Ghosh, A Das - 2020 - chemrxiv.org
SARS-CoV-2 or COVID-19 has caused more than 10, 00,000 infections and~ 55,000 deaths
worldwide spanning over 203 countries, and the numbers are exponentially increasing. Due …

Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs

VL Kouznetsova, A Zhang, M Tatineni, MA Miller… - PeerJ, 2020 - peerj.com
Using the crystal structure of SARS-CoV-2 papain-like protease (PL pro) as a template, we
developed a pharmacophore model of functional centers of the PL pro inhibitor-binding …

Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat's Claw) against the Main Protease 3CLpro of SARS‐CoV‐2 by Molecular Modeling

AF Yepes-Pérez, O Herrera-Calderon… - Evidence‐Based …, 2020 - Wiley Online Library
COVID‐19 is a disease caused by severe acute respiratory syndrome coronavirus 2.
Presently, there is no effective treatment for COVID‐19. As part of the worldwide efforts to …

Discovery of potential SARS-CoV-2 papain-like protease natural inhibitors employing a multi-phase in silico approach

EB Elkaeed, AM Metwaly, MS Alesawy, AM Saleh… - Life, 2022 - mdpi.com
As an extension of our research against COVID-19, a multiphase in silico approach was
applied in the selection of the three most common inhibitors (Glycyrrhizoflavone (76) …

Targeting papain-like protease by natural products as novel therapeutic potential SARS-CoV-2

M Waqas, S Ullah, SA Halim, NU Rehman, A Ali… - International Journal of …, 2024 - Elsevier
The highly infectious respiratory illness 'COVID-19'was caused by SARS-CoV-2 and is
responsible for millions of deaths. SARS-single-stranded viral RNA genome encodes …

Potential inhibitors targeting papain-like protease of SARS-CoV-2: two birds with one stone

H Jiang, P Yang, J Zhang - Frontiers in chemistry, 2022 - frontiersin.org
Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …

Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants

GA Gyebi, OB Ogunro, AP Adegunloye… - Journal of …, 2021 - Taylor & Francis
The novel coronavirus disease 2019 (COVID-19) caused by SARS-COV-2 has raised
myriad of global concerns. There is currently no FDA approved antiviral strategy to alleviate …

Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and a FlipGFP-based reporter assay

C Ma, MD Sacco, Z Xia, G Lambrinidis… - ACS central …, 2021 - ACS Publications
The papain-like protease (PLpro) of SARS-CoV-2 is a validated antiviral drug target.
Through a fluorescence resonance energy transfer-based high-throughput screening and …

Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases

Z Chen, Q Cui, L Cooper, P Zhang, H Lee, Z Chen… - Cell & Bioscience, 2021 - Springer
Background In the urgent campaign to develop therapeutics against SARS-CoV-2, natural
products have been an important source of new lead compounds. Results We herein …

Structure-based virtual screening suggests inhibitors of 3-Chymotrypsin-Like Protease of SARS-CoV-2 from Vernonia amygdalina and Occinum gratissimum

GA Gyebi, AA Elfiky, OM Ogunyemi, IM Ibrahim… - Computers in Biology …, 2021 - Elsevier
Antiviral culinary plants are potential bioresources for preventive nutraceuticals and/or
antiviral drugs in COVID-19. Structure-based virtual screening was undertaken to screen …