Type III interferons (IFNs)(interleukin-28/29 or lambda interferon [IFN-λ]) are cytokines with
IFN-like activities. Here we show that several classes of viruses induce expression of IFN-λ1 …

The first line of defense against viral infections is mediated by interferons (IFN) s, which are
produced rapidly by the infected host. Type I IFNs (IFN-α/β) are known to combat viruses …

The discovery and initial description of the interferon-λ (IFN-λ) family in early 2003 opened
an exciting new chapter in the field of IFN research. There are 3 IFN-λ genes that encode 3 …

The interferon lambda family (IFN-λ1/2/3) is a newly described group of cytokines that are
related to both the type-1 interferons and IL-10 family members. These novel cytokines are …

Type III interferon (IFN) or IFN-λ is a recently discovered family of IFNs that signal through
the same downstream transcription factors as type I IFN but use a separate receptor complex …

Interferons (IFNs) can serve as the first line of immune defense against viral infection. The
identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral …

Interferon-λ (IFN-λ) is an antiviral cytokine that signals through a distinct receptor complex,
composed of the IFN-λR1 and interleukin-10R2 (IL-10R2) receptor chains. We have …

Despite binding to receptors distinct from those of type I interferons (IFNs), human
interleukins-28A,-28B and-29 (IL-28A, IL-28B and IL-29; alternatively named IFN lambda-2 …

With increasing interest in alternative options to interferon‐alpha‐based treatments, IFN‐λ
has shown therapeutic promise in a variety of diseases. Although the antiviral activity of IFN …

Human interferon lambdas (IFN-λ s)(type III IFNs) exhibit antiviral activity in vitro by binding
to a receptor complex distinct from that used by type I and type II IFNs, and subsequent …