Cystic fibrosis is the most common life-shortening genetic disease affecting Caucasians,
clinically manifested by fat malabsorption, poor growth and nutrition, and recurrent …

The introduction and widespread implementation of newborn bloodspot screening (NBS) for
cystic fibrosis (CF) has offered earlier diagnosis and better outcomes for children with CF in …

In the not-too-distant past, parents were counseled that children with cystic fibrosis were
unlikely to live past their teenage years. But a new estimate of patients' life spans suggests …

During the past quarter century, the diagnosis and treatment of cystic fibrosis (CF) have
been transformed by molecular sciences that initiated a new era with discovery of the cystic …

The treatment of people with cystic fibrosis (CF) has been transformed by the availability of
drugs that target the basic chloride defect in the disease. The use of drugs that target specific …

INTRODUCTION Cystic fibrosis (CF) is a genetic disorder that leads to chronic multisystem
disease consisting of chronic sinopulmonary infections, malabsorption, and nutritional …

The first regulatory approval for a drug developed specifically for cystic fibrosis (CF)
occurred in 1993, and since then, several other drugs have been approved. Median …

There have been dramatic changes in the care of children with cystic fibrosis (CF) from 1965
to 2015. The initial improvements were the result of incremental gains in medical knowledge …

The diagnosis of cystic fibrosis (CF) has traditionally relied on the presence of clinical
features of the disease. Today, diagnosis through newborn screening (NBS) is becoming the …

CFTR modulators promise to transform the therapeutic landscape in CF in a precision based
fashion. Areas of ongoing research include developing drugs for all mutation classes so that …