[HTML][HTML] PSMA-targeted combination brusatol and docetaxel nanotherapeutics for the treatment of prostate cancer

TA Adekiya, T Hudson, O Bakare, EE Ameyaw… - Biomedicine & …, 2024 - Elsevier
Active targeting to cancer involves exploiting specific interactions between receptors on the
surface of cancer cells and targeting moieties conjugated to the surface of vectors such that …

Glutamate-urea-based PSMA-targeted PLGA nanoparticles for prostate cancer delivery of docetaxel

F Saniee, N Shabani Ravari, N Goodarzi… - Pharmaceutical …, 2021 - Taylor & Francis
Targeted drug delivery is a tool to make treatment more specific, selective, and effective and
to prevent unwanted complications. Prostate specific membrane antigen (PSMA) is a useful …

Characterization of a targeted nanoparticle functionalized with a urea-based inhibitor of prostate-specific membrane antigen (PSMA)

SS Chandran, S R. Banerjee, R C. Mease… - Cancer biology & …, 2008 - Taylor & Francis
Polymeric nanoparticles represent a form of targeted therapy due to their ability to passively
accumulate within the tumor interstitium via the enhanced permeability and retention (EPR) …

Synthesis and biological evaluation of PSMA-targeting paclitaxel conjugates

AE Machulkin, DA Skvortsov, YA Ivanenkov… - Bioorganic & Medicinal …, 2019 - Elsevier
Prostate cancer (PC) is the second most commonly occurring cancer in men. Conventional
chemotherapy has wide variety of disadvantages such as high systemic toxicity and low …

J591 functionalized paclitaxel-loaded PLGA nanoparticles successfully inhibited PSMA overexpressing LNCaP cells

I Ehsan, L Kumari, R Sen, A Al Hoque… - Journal of Drug Delivery …, 2022 - Elsevier
To evaluate the chemotherapeutic efficacy of J591 fabricated poly (d, l)-lactic-co-glycolic
acid (PLGA) nanoparticles containing paclitaxel (Ab-PTX-NP) in vitro in PSMA (prostate …

[HTML][HTML] PSMA-targeted theranostic nanocarrier for prostate cancer

O Flores, S Santra, C Kaittanis, R Bassiouni… - Theranostics, 2017 - ncbi.nlm.nih.gov
Herein, we report the use of a theranostic nanocarrier (Folate-HBPE (CT20p)) to deliver a
therapeutic peptide to prostate cancer tumors that express PSMA (folate hydrolase 1). The …

Old drug, new delivery strategy: MMAE repackaged

H Lahnif, T Grus, EA Salvanou, E Deligianni… - International Journal of …, 2023 - mdpi.com
Targeting therapy is a concept that has gained significant importance in recent years,
especially in oncology. The severe dose-limiting side effects of chemotherapy necessitate …

Design of chitosan-coated, quercetin-loaded PLGA nanoparticles for enhanced PSMA-specific activity on LnCap prostate cancer cells

D Essa, PPD Kondiah, P Kumar, YE Choonara - Biomedicines, 2023 - mdpi.com
Nanoparticles are designed to entrap drugs at a high concentration, escape clearance by
the immune system, be selectively taken up by cancer cells, and release bioactives in a rate …

Surface modification of liposomes by a lipopolymer targeting prostate specific membrane antigen for theranostic delivery in prostate cancer

H Yari, G Nkepang, V Awasthi - Materials, 2019 - mdpi.com
Prostate specific membrane antigen (PSMA) is a marker for diagnosis and targeted delivery
of therapeutics to advanced/metastasized prostate cancer. We report a liposome-based …

PEG‐PLA nanoparticles decorated with small‐molecule PSMA ligand for targeted delivery of galbanic acid and docetaxel to prostate cancer cells

M Afsharzadeh, M Hashemi, M Babaei… - Journal of Cellular …, 2020 - Wiley Online Library
Prostate cancer (PCa) is one of the most prevalent non‐drug delivery system cutaneous
malignancies. Undoubtedly, introducing novel treatment options to achieve higher …