Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …

Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Increased life expectancies have significantly increased the number of individuals suffering
from geriatric neurodegenerative diseases such as Alzheimer's disease (AD) and …

Aging is the major predictor for developing multiple neurodegenerative diseases, including
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Cellular senescence is a state of permanent cell-cycle arrest. Early in life, senescence has a
physiologic role in tumor suppression and wound healing. However, gradually, as these …

In 1960, Rita Levi-Montalcini and Barbara Booker made an observation that transformed
neuroscience: as neurons mature, they become apoptosis resistant. The following year …

Significance: Cellular senescence, characterized by permanent cell cycle arrest, has been
extensively studied in mitotic cells such as fibroblasts. However, senescent cells have also …

Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

The term cellular senescence was introduced more than five decades ago to describe the
state of growth arrest observed in aging cells. Since this initial discovery, the phenotypes …