The functional capacity of cells is defined by the transcriptome. Many recent studies have
identified variations in the transcriptome of tumors due to alternative splicing changes, as …

Recent progress in global sequence and microarray data analysis has revealed the
increasing complexity of the human transcriptome. Alternative splicing generates a huge …

Alternative splicing is a key molecular mechanism for increasing the functional diversity of
the eukaryotic proteomes. A large body of experimental data implicates aberrant splicing in …

Pre-messenger RNA splicing is a fine-tuned process that generates multiple functional
variants from individual genes. Various cell types and developmental stages regulate …

Numerous studies report splicing alterations in a multitude of cancers by using gene‐by‐
gene analysis. However, understanding of the role of alternative splicing in cancer is now …

Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …

In past decades, cancer research has focused on genetic alterations that are detected in
malignant tissues and contribute to the initiation and progression of cancer. These changes …

Over the past decade there has been increased awareness of the potential role of
alternative splicing in the etiology of cancer. In particular, advances in RNA-Sequencing …

Cancer arises from alterations in several metabolic processes affecting proliferation, growth,
replication and death of cells. A fundamental challenge in the study of cancer biology is to …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …