A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

KA Pooley, SE Bojesen, M Weischer… - Human molecular …, 2013 - academic.oup.com
Mean telomere length (TL) in blood cells is heritable and has been reported to be
associated with risks of several diseases, including cancer. We conducted a meta-analysis …

Assessing the relationship between leukocyte telomere length and cancer risk/mortality in UK biobank and TCGA datasets with the genetic risk score and Mendelian …

Y Gao, Y Wei, X Zhou, S Huang, H Zhao… - Frontiers in …, 2020 - frontiersin.org
Background Telomere length is an important indicator of tumor progression and survival for
cancer patients. Previous work investigated the associations between genetically predicted …

Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

M Mangino, SJ Hwang, TD Spector… - Human molecular …, 2012 - academic.oup.com
Leukocyte telomere length (LTL) is associated with a number of common age-related
diseases and is a heritable trait. Previous genome-wide association studies (GWASs) …

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

MA Taub, MP Conomos, R Keener, KR Iyer… - Cell Genomics, 2022 - cell.com
Genetic studies on telomere length are important for understanding age-related diseases.
Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here …

Identification of seven loci affecting mean telomere length and their association with disease

V Codd, CP Nelson, E Albrecht, M Mangino, J Deelen… - Nature …, 2013 - nature.com
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Genome-wide association analysis in humans links nucleotide metabolism to leukocyte telomere length

C Li, S Stoma, LA Lotta, S Warner, E Albrecht… - The American Journal of …, 2020 - cell.com
Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …

Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk

KL Terry, SS Tworoger, AF Vitonis, J Wong… - … , biomarkers & prevention, 2012 - AACR
Background: Telomeres protect chromosomal ends, shorten with cellular division, and signal
cellular senescence, but unchecked telomere attrition can lead to telomere dysfunction …

[HTML][HTML] Epigenome-wide association study of leukocyte telomere length

Y Lee, D Sun, APS Ori, AT Lu, A Seeboth… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Telomere length is associated with age-related diseases and is highly heritable. It is unclear,
however, to what extent epigenetic modifications are associated with leukocyte telomere …

Telomere length and common disease: study design and analytical challenges

JH Barrett, MM Iles, AM Dunning, KA Pooley - Human genetics, 2015 - Springer
Telomeres, the repetitive sequences that protect the ends of chromosomes, help to maintain
genomic integrity and are of key importance to human health. The aim here is to give an …

A Genome-Wide Association Study Identifies a Locus on TERT for Mean Telomere Length in Han Chinese

Y Liu, L Cao, Z Li, D Zhou, W Liu, Q Shen, Y Wu… - PloS one, 2014 - journals.plos.org
Leukocyte telomere length (LTL) is a predictor of aging and a number of age-related
diseases. We performed genome-wide association studies of mean LTL in 2632 individuals …