Multiple sclerosis (MS) is most likely to adopt a progressive clinical course during middle
age or beyond, and the number of older adults with MS is steadily increasing. Developing …

Aging is one of the most important risk factors for the development of several
neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular …

Multiple sclerosis (MS) is a chronic and often progressive, demyelinating disease of the
central nervous system (CNS) white and gray matter and the single most common cause of …

Abstract Purpose of Review Multiple sclerosis (MS) is a chronic, immune-mediated
demyelinating disorder of the central nervous system. Age is one of the most important …

Abstract Purpose of Review The purpose of this review is to discuss the interaction between
aging, progressive disease course, disability worsening, and treatment strategies in multiple …

Remyelination is a physiological response to demyelinating events aiming to restore
saltatory conduction and preserve axonal integrity. Resident oligodendrocyte precursor cells …

The life expectancy and average age of persons with multiple sclerosis (MS) have increased
significantly during the last two decades. The introduction of disease-modifying therapies …

A better understanding of the pathological mechanisms that drive neurodegeneration in
people living with multiple sclerosis (MS) is needed to design effective therapies to treat …

The prevalence of multiple sclerosis (MS) and the age of affected patients are increasing
owing to increased longevity of the general population and the availability of effective …

Recent studies have implicated cellular senescence as a disease-related process linked to
progressive forms of multiple sclerosis (MS). Herein, we present an overview of the current …