Abstract T regulatory Type 1 (Tr1) cells are adaptive T regulatory cells characterized by the
ability to secrete high levels of IL-10 and minimal amounts of IL-4 and IL-17. Recently …

The immune system is composed of effectors and regulators. Type 1 regulatory T (Tr1) cells
are classified as a distinct subset of T cells, and they secret high levels of IL-10 but lack the …

Peripheral tolerance is mediated by multiple mechanisms such as anergy and/or active
suppression of effector T cells by T regulatory (Tr) cells. Among the CD4+ Tr cells, T …

Interleukin‐10 (IL‐10)‐secreting T regulatory type 1 (Tr1) cells are defined by their specific
cytokine production profile, which includes the secretion of high levels of IL‐10 and …

Regulatory T cell–mediated suppression serves as a pivotal mechanism of negative
regulation of immune‐mediated inflammation. Type 1 regulatory T cells (Tr1 cells) are an …

T regulatory cells, a specialized subset of T cells, are key players in modulating antigen (Ag)-
specific immune responses in vivo. Inducible T regulatory type 1 (Tr1) cells are …

Thirty years ago, one of the first types of CD4+ T regulatory cells was discovered and named
T regulatory type 1 (Tr1) cells. Tr1 cells represent a distinct population of T cells, which are …

Abstract Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and
play a key role in maintaining tolerance to self-and non–self-antigens. Interleukin-10 (IL-10) …

The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have
been widely studied over the years. However, several recent discoveries have shed new …

Suppression by T regulatory (Tr) cells is essential for induction of tolerance. Many types of Tr
cells have been described in a number of systems, and their biology has been the subject of …