The NLRP3 inflammasome is an intracellular, multimeric protein complex that initiates a
potent inflammatory response to danger signals. After acute myocardial infarction, NLRP3 …

An accumulating body of evidence indicates that NLRP3 inflammasome plays a crucial role
in the pathophysiology of cardiovascular diseases, including atherosclerosis and acute …

The NLRP3 inflammasome may contribute to infarct development during acute cardiac
ischemia-reperfusion (IR). Because infarct size strongly correlates with the degree of heart …

An accumulating body of evidence indicates that inflammation plays a crucial role in the
pathophysiology of myocardial infarction (MI). Nucleotide-binding oligomerization domain …

Background: Activation of the NLRP3 inflammasome is a primary driver of sterile
inflammation in response to myocardial ischemia reperfusion. Pharmacologic inhibitors of …

Acute myocardial infarction (AMI) is associated with the induction of a sterile inflammatory
response that leads to further injury. The NACHT, leucine-rich repeat, and pyrin domain …

Aims Myocardial infarction (MI) triggers an intense inflammatory response that is associated
with infarct expansion and is detrimental for cardiac function. Interleukin (IL)-1β and IL-18 …

Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity
worldwide. Atherosclerosis is responsible for the majority of cardiovascular disorders with …

The heart is extremely sensitive to ischaemic injury. During an acute myocardial infarction
(AMI) event, the injury is initially caused by reduced blood supply to the tissues, which is …

NLRP3 inflammasome is a key multiprotein signaling platform that tightly controls
inflammatory responses and coordinates antimicrobial host defenses by activating caspase …