Gene promoters typically contain multiple transcription factor binding sites (TFBSs), which
may vary in affinity for their cognate transcription factors (TFs). One major challenge in …

Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control
of gene expression. Despite many advances in the characterization of sequence motifs …

Variations in noncoding regulatory sequences play a central role in evolution. Interpreting
such variations, however, remains difficult even in the context of defined attributes such as …

Statistical models have been used to quantify the relationship between gene expression and
transcription factor (TF) binding signals. Here we apply the models to the large-scale data …

Transcriptional regulation requires the binding of transcription factors (TFs) to short
sequence-specific DNA motifs, usually located at the gene regulatory regions. Interestingly …

Most eukaryotic transcription factors (TFs) are part of large protein families, with members of
the same family (ie, paralogous TFs) recognizing similar DNA-binding motifs but performing …

Recent technological advances have made it possible to determine the genome-wide
binding sites of transcription factors (TFs). Comparisons across species have suggested a …

Despite much research, our understanding of the architecture and cis-regulatory elements of
human promoters is still lacking. Here, we devised a high-throughput assay to quantify the …

Identifying transcription factors (TF) involved in producing a genome-wide transcriptional
profile is an essential step in building mechanistic model that can explain observed gene …

The prediction of transcription factor (TF) activities from the gene expression of their targets
(ie, TF regulon) is becoming a widely used approach to characterize the functional status of …