TNF-α and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica
N Takahashi, S Kikuchi, VI Shubayev, WM Campana… - Spine, 2006 - journals.lww.com
Study Design. Characterize extracellular signal-regulated kinase (ERK) and its
phosphorylation (pERK) in neural tissues after topical application of tumor necrosis factor …
phosphorylation (pERK) in neural tissues after topical application of tumor necrosis factor …
Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuritis of the nerve root
Y Kominato, T Tachibana, Y Dai, H Tsujino, S Maruo… - Brain research, 2003 - Elsevier
Mechanical compression and chemical inflammation of the spinal nerve root are considered
major sensory pathologies secondary to a lumbar disc herniation. In order to elucidate the …
major sensory pathologies secondary to a lumbar disc herniation. In order to elucidate the …
ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase
(MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent …
(MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent …
Extracellular signal-regulated kinase mitogen-activated protein kinase activation in the dorsal root ganglion (DRG) and spinal cord after DRG injury in rats
H Doya, S Ohtori, K Takahashi, Y Aoki, H Ino… - Spine, 2005 - journals.lww.com
Study Design. We investigated the extracellular signal-regulated kinase (ERK) activation by
immunohistochemically detecting phosphorylated ERK (pERK) in the dorsal root ganglion …
immunohistochemically detecting phosphorylated ERK (pERK) in the dorsal root ganglion …
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain …
Activation of ERK (extracellular signal-regulated kinase) MAP (mitogen-activated protein)
kinase in dorsal horn neurons of the spinal cord by peripheral noxious stimulation …
kinase in dorsal horn neurons of the spinal cord by peripheral noxious stimulation …
The activation of extracellular signal-regulated protein kinase 5 in spinal cord and dorsal root ganglia contributes to inflammatory pain
C Xiao, L Zhang, QP Cheng, LC Zhang - Brain research, 2008 - Elsevier
Activation of mitogen-activated protein kinases (MAPKs) in dorsal root ganglia (DRG) and
the spinal dorsal horn contributes to inflammatory pain by transcription-dependent and …
the spinal dorsal horn contributes to inflammatory pain by transcription-dependent and …
Activation of extracellular signal-regulated protein kinase in the dorsal root ganglion following inflammation near the nerve cell body
K Obata, H Yamanaka, Y Dai, T Mizushima, T Fukuoka… - Neuroscience, 2004 - Elsevier
Inflammation of the primary afferent proximal to the dorsal root ganglion (DRG) and the DRG
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …
itself is known to produce radicular pain. Here, we examined pain-related behaviors and the …
ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity
X Zhang, H Zhang, H Shao, Q Xue, B Yu - PloS one, 2014 - journals.plos.org
Cyclin-dependent kinase 5 is a proline-directed serine/threonine kinase and its activity
participates in the regulation of nociceptive signaling. Like binding with the activators (P35 …
participates in the regulation of nociceptive signaling. Like binding with the activators (P35 …
The ERK/MAPK pathway, as a target for the treatment of neuropathic pain
W Ma, R Quirion - Expert opinion on therapeutic targets, 2005 - Taylor & Francis
Peripheral nerve injury produces neuropathic pain as well as phosphorylation of mitogen
activated protein kinase (MAPK) family in dorsal root ganglia (DRG) and dorsal horn …
activated protein kinase (MAPK) family in dorsal root ganglia (DRG) and dorsal horn …
Activation of spinal ERK1/2 contributes to mechanical allodynia in a rat model of postoperative pain
XD Shi, D Fu, JM Xu, YL Zhang… - Molecular Medicine …, 2013 - spandidos-publications.com
Extracellular signal-regulated kinase (ERK) 1/2 in the spinal cord has been implicated in the
development of neuropathic pain and inflammatory pain. However, a limited number of …
development of neuropathic pain and inflammatory pain. However, a limited number of …