IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)
A Dunne, S Carpenter, C Brikos, P Gray… - Journal of Biological …, 2010 - ASBMB
Signal transduction by Toll-like receptor 2 (TLR2) and TLR4 requires the adaptors MyD88
and Mal (MyD88 adaptor-like) and serine/threonine kinases, interleukin-1 receptor …
and Mal (MyD88 adaptor-like) and serine/threonine kinases, interleukin-1 receptor …
IRAK‐M mediates Toll‐like receptor/IL‐1R‐induced NFκB activation and cytokine production
Toll‐like receptors transduce their signals through the adaptor molecule MyD88 and
members of the IL‐1R‐associated kinase family (IRAK‐1, 2, M and 4). IRAK‐1 and IRAK‐2 …
members of the IL‐1R‐associated kinase family (IRAK‐1, 2, M and 4). IRAK‐1 and IRAK‐2 …
[HTML][HTML] IRAK-M is a negative regulator of Toll-like receptor signaling
K Kobayashi, LD Hernandez, JE Galán, CA Janeway… - Cell, 2002 - cell.com
Toll-like receptors (TLRs) detect microorganisms and protect multicellular organisms from
infection. TLRs transduce their signals through MyD88 and the serine/threonine kinase …
infection. TLRs transduce their signals through MyD88 and the serine/threonine kinase …
A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling
N Rao, S Nguyen, K Ngo… - Molecular and cellular …, 2005 - Am Soc Microbiol
Abstract The interleukin-1 (IL-1) receptor-associated kinase 1 (IRAK1) is a member of the
IRAK kinase family that plays a pivotal role in the Toll/IL-1 receptor (TIR) family signaling …
IRAK kinase family that plays a pivotal role in the Toll/IL-1 receptor (TIR) family signaling …
The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory
MP Hardy, LAJ O'Neill - Journal of Biological Chemistry, 2004 - ASBMB
The interleukin-1 receptor-associated kinases (IRAKs) are important downstream signaling
components of Toll-like receptors (TLRs). To date, four mammalian IRAKs have been found …
components of Toll-like receptors (TLRs). To date, four mammalian IRAKs have been found …
IRAK-4 as the central TIR signaling mediator in innate immunity
N Suzuki, S Suzuki, WC Yeh - Trends in immunology, 2002 - cell.com
Abstract Toll-like receptors (TLRs), which recognize pathogen-associated molecular
patterns and members of the proinflammatory interleukin-1 receptor (IL-1R) family, share …
patterns and members of the proinflammatory interleukin-1 receptor (IL-1R) family, share …
Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling
S De, F Karim, E Kiessu, L Cushing, LL Lin… - Journal of Biological …, 2018 - ASBMB
Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a central regulator of innate
immune signaling, controlling IL1R and Toll-like receptor (TLR)-mediated responses and …
immune signaling, controlling IL1R and Toll-like receptor (TLR)-mediated responses and …
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
K Burns, S Janssens, B Brissoni, N Olivos… - The Journal of …, 2003 - rupress.org
Toll-like receptors (TLRs) and members of the proinflammatory interleukin 1 receptor (IL-1R)
family are dependent on the presence of MyD88 for efficient signal transduction. The …
family are dependent on the presence of MyD88 for efficient signal transduction. The …
Interleukin‐1 receptor‐associated kinase‐1 (IRAK‐1): A self‐regulatory adapter molecule in the signaling cascade of the Toll/IL‐1 receptor family
MU Martin, C Kollewe - Signal Transduction, 2001 - Wiley Online Library
The human Interleukin‐1 receptor‐associated protein kinase IRAK‐1 is a highly specific
signaling molecule activated by the Toll/IL‐1 receptor family. It is a multidomain protein …
signaling molecule activated by the Toll/IL‐1 receptor family. It is a multidomain protein …
Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein
F Hatao, M Muroi, N Hiki, T Ogawa… - Journal of leukocyte …, 2004 - academic.oup.com
Abstract Interleukin-1 receptor-associated kinase (IRAK)-4 is a key mediator in the Toll-like
receptor (TLR) signaling. We found that stimulation of TLR2, TLR4, or TLR9, but not TLR3 …
receptor (TLR) signaling. We found that stimulation of TLR2, TLR4, or TLR9, but not TLR3 …