The human SOX2 gene was recently identified as a novel major oncogene, recurrently
amplified and overexpressed in esophageal squamous cell carcinoma (ESCC). However …

Purpose: By using cDNA microarray analysis, we identified a transcriptional factor, SOX6,
was frequently downregulated in esophageal squamous cell carcinoma (ESCC). The aim of …

Background Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy lacking
valid prognostic biomarkers. As a member of the High Mobility Group domain-containing …

The transcription factor SOX 2 is essential for the maintenance of embryonic stem cells and
normal development of the esophagus. Our previous study revealed that the SOX2 gene is …

Purpose Gastrointestinal (GI) malignancies are among the 5 most common cancers in Iran,
and their high associated mortality rates are attributable to late diagnosis and poor treatment …

Background: Sex-determining region Y-box 9 (SOX9) is an important transcription factor for
the development and differentiation of cells and their organization. In the present study, the …

Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It
also plays an important role in tissue homeostasis and regeneration, maintaining the …

Sex-determining region Y (SRY)-box 1 (SOX1) as a member of the SOX gene superfamily is
reported to function as a tumor suppressor in hepatocelluar cancer (HCC). However, the …

SOX transcription factors are essential for embryonic development and play critical roles in
cell fate determination, differentiation and proliferation. We previously reported that the …

Hepatocellular carcinoma (HCC) is a common malignant tumor lacking sensitive biomarkers
for prognosis. Sox3, a member of the Sex determining region Y box gene superfamily, has …