Cytokines and their relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19): a retrospective cohort study

QQ Liu, A Cheng, Y Wang, H Li, L Hu, X Zhao… - BMJ open, 2020 - bmjopen.bmj.com
Objective To delineate the characteristics and clinical significance of plasma inflammatory
cytokines altered in COVID-19. Design Retrospective, single-centre cohort study. Setting …

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

H Han, Q Ma, C Li, R Liu, L Zhao, W Wang… - Emerging microbes & …, 2020 - Taylor & Francis
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly
spread across many other countries. While the majority of patients were considered mild …

Aberrant cytokine expression in COVID-19 patients: Associations between cytokines and disease severity

Y Tang, J Sun, H Pan, F Yao, Y Yuan, M Zeng, G Ye… - Cytokine, 2021 - Elsevier
Cytokines play pleiotropic, antagonistic, and collaborative in viral disease. The high
morbidity and mortality of coronavirus disease 2019 (COVID-19) make it a significant threat …

[PDF][PDF] IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression

SK Dhar, K Vishnupriyan, S Damodar, S Gujar, M Das - Heliyon, 2021 - cell.com
Abstract Aims SARS-CoV-2, an infectious agent behind the ongoing COVID-19 pandemic,
induces high levels of cytokines such as IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ etc in …

Immunity and inflammatory biomarkers in COVID‐19: a systematic review

APD Iwamura, MR Tavares da Silva… - Reviews in medical …, 2021 - Wiley Online Library
Summary Coronavirus disease 2019 (COVID‐19) is a clinical syndrome caused by the
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus. Patients can be …

The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro …

BM Henry, SW Benoit, J Vikse, BA Berger… - Clinical Chemistry and …, 2021 - degruyter.com
Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated
immune state. While research has focused on the hyperinflammation, little research has …

Elevated interleukin levels are associated with higher severity and mortality in COVID 19–a systematic review, meta-analysis, and meta-regression

E Yonas, I Alwi, R Pranata, I Huang, MA Lim… - Diabetes & Metabolic …, 2020 - Elsevier
Background and aims COVID 19 pneumonia commonly leads to ARDS. The occurrence of
ARDS in COVID 19 patients is thought to occur secondary to an exaggerated immunologic …

Circulating levels of interleukin-6 and interleukin-10, but not tumor necrosis factor-alpha, as potential biomarkers of severity and mortality for COVID-19: systematic …

W Udomsinprasert, J Jittikoon… - Journal of clinical …, 2021 - Springer
Purpose Cytokine storm, an uncontrolled overproduction of inflammatory cytokines
contributing to an aberrant systemic inflammatory response, is a major pathological feature …

Cytokine signature associated with disease severity in COVID-19

J Guo, S Wang, H Xia, D Shi, Y Chen, S Zheng… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) broke out and then became a global epidemic at the
end of 2019. With the increasing number of deaths, early identification of disease severity …

Dynamic changes in serum IL-6, IL-8, and IL-10 are associated with the outcome of patients with severe COVID-19 in ICU

J Li, L Rong, R Cui, J Feng, Y Jin, Y Yu, X Chen, R Xu - 2020 - researchsquare.com
Background: Biomarkers that would help prognosticate outcomes and guide treatment of
patients with severe coronavirus disease 2019 (COVID-19) are currently required. We aimed …