Decreased complement C3 levels are associated with poor prognosis in patients with COVID-19: A retrospective cohort study

S Fang, H Wang, L Lu, Y Jia, Z Xia - International immunopharmacology, 2020 - Elsevier
Objectives To describe the humoral immune feature of patients with coronavirus disease
2019 (COVID-19). Methods The levels of total immunoglobulins (IgG, IgM, IgA, and IgE) …

T-Cell subsets and interleukin-10 levels are predictors of severity and mortality in COVID-19: A systematic review and meta-analysis

AF Alshammary, JM Alsughayyir, KK Alharbi… - Frontiers in …, 2022 - frontiersin.org
Background Many COVID-19 patients reveal a marked decrease in their lymphocyte counts,
a condition that translates clinically into immunodepression and is common among these …

Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China

R Chen, L Sang, M Jiang, Z Yang, N Jia, W Fu… - Journal of Allergy and …, 2020 - Elsevier
Background Crucial roles of hematologic and immunologic responses in progression of
coronavirus disease 2019 (COVID-19) remain largely unclear. Objective We sought to …

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …

IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19

RL Luporini, JMA Rodolpho, LT Kubota, ACBM Martin… - Cytokine, 2021 - Elsevier
Aim COVID-19 pandemic has caused extensive burden on public life and health care
worldwide. This study aimed to assess circulating levels of inflammatory cytokines in adult …

Blood interferon-α levels and severity, outcomes, and inflammatory profiles in hospitalized COVID-19 patients

M Contoli, A Papi, L Tomassetti, P Rizzo… - Frontiers in …, 2021 - frontiersin.org
Background: Deficient interferon responses have been proposed as one of the relevant
mechanisms prompting severe manifestations of COVID-19. Objective: To evaluate the …

Serum cytokine and chemokine profile in relation to the severity of coronavirus disease 2019 in China

Y Chi, Y Ge, B Wu, W Zhang, T Wu… - The Journal of …, 2020 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused
by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We investigated the …

Characteristics of lymphocyte subsets and cytokine profiles of patients with COVID-19

P Pan, X Du, Q Zhou, Y Cui, X Deng, C Liu, Z Hu… - Virology Journal, 2022 - Springer
Background Abnormalities of lymphocyte subsets and cytokine profiles have been observed
in most patients with coronavirus disease (COVID-19). Here, we explore the role of …

The diagnostic and predictive role of NLR, d-NLR and PLR in COVID-19 patients

AP Yang, J Liu, W Tao, H Li - International immunopharmacology, 2020 - Elsevier
Aim To accumulate evidence that indicated the key role played by virus-triggered
inflammation in the 2019-novel coronavirus disease (COVID-19) which emerged in Wuhan …

The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis

H Akbari, R Tabrizi, KB Lankarani, H Aria, S Vakili… - Life sciences, 2020 - Elsevier
Aims This study aimed to make a comparison between the clinical laboratory-related factors,
complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to …