Plasma coagulation factor XIII (FXIII) is a pro-transglutaminase essential for haemostasis
which, after being activated by thrombin and Ca2+, plays an important role in the final stages …

BACKGROUND AND OBJECTIVE: Several hereditary disorders affecting coagulation factors
have been identified as prothrombotic risk factors. Recently, the common Val34Leu …

Variations in plasma levels of factor XI (FXI), the serine protease involved in the amplification
of thrombin generation via the intrinsic pathway [1], draw particular interest for …

The precise role of factor XII (FXII) in the regulation of blood coagulation and fibrinolysis is
still undefined. Activation of FXII initiates both the kinin-forming cascade and the intrinsic …

In a family-based study called GAIT (Genetic Analysis of Idiopathic Thrombophilia) that
included a genome-wide scan we demonstrated that a polymorphism (46C→ T) in the F12 …

Factor XIII a subunit (F13A) is the last enzyme in the blood coagulation cascade. It is
characterized by extensive genetic polymorphism defined by 4 common alleles, F13A* 1A …

Background and Purpose—Ischemic stroke (IS) is a complex disease that involves genetic
and environmental factors. In a family-based study (the Genetic Analysis of Idiopathic …

Background Activated factor XIII (FXIII) cross-links between fibrin monomers, thus increasing
the clot stability and resistance to fibrinolysis. Congenital FXIII deficiency causes severe …

Background Plasma factor VII concentrations (FVIIa), a marker of coronary artery disease
(CAD) risk, are influenced by genetic markers at the promoter site: the A2 allele, due to a …

Abstract The common F12-4 C> T polymorphism significantly regulates plasma levels of
FXII, the first element of the intrinsic pathway of coagulation. Due to the robust effects that …