Clinical characteristics and immune injury mechanisms in 71 patients with COVID-19

Y Wu, X Huang, J Sun, T Xie, Y Lei, J Muhammad, X Li… - Msphere, 2020 - Am Soc Microbiol
The outbreak of coronavirus disease 2019 (COVID-19), caused by the novel coronavirus
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a threat to …

Immune system changes during COVID-19 recovery play key role in determining disease severity

F Fathi, R Sami, S Mozafarpoor… - International journal …, 2020 - journals.sagepub.com
Coronavirus disease 2019 (COVID-19), an acute respiratory infection, is largely associated
with dysregulation and impairment of the immune system. This study investigated how the …

Immunological and inflammatory profiles during acute and convalescent phases of severe/critically ill COVID-19 patients

Q Chen, B Yu, Y Yang, J Huang, Y Liang, J Zhou… - International …, 2021 - Elsevier
Abstract Background The 2019 Coronavirus (COVID-19) pandemic poses a huge threat
internationally; however, the role of the host immune system in the pathogenesis of COVID …

Lymphocyte subset alteration and monocyte CD4 expression reduction in patients with severe COVID-19

S Kazancioglu, FM Yilmaz, A Bastug, A Sakallı… - Viral …, 2021 - liebertpub.com
The spectrum of coronavirus disease 2019 (COVID-19) severity, related to cellular immune
functions, has not been fully clarified yet. Therefore, this study aimed to investigate the …

Characterizing the immune responses of those who survived or succumbed to COVID-19: Can immunological signatures predict outcome?

R Sami, F Fathi, N Eskandari, M Ahmadi, R ArefNezhad… - Cytokine, 2021 - Elsevier
Background Immunodeficiency has pivotal role in the pathogenesis of coronavirus disease
2019 (COVID-19). Several studies have indicated defects in the immune system of COVID …

Immune characteristics of severe and critical COVID-19 patients

L Yang, J Gou, J Gao, L Huang, Z Zhu, S Ji… - Signal transduction and …, 2020 - nature.com
Recently, the novel coronavirus disease (COVID-19) has broken out worldwide, 1 with rapid
increase of infected patients. COVID-19 dominantly leads to pneumonia. 2 Among these …

Immune dysfunction following COVID-19, especially in severe patients

CY Song, J Xu, JQ He, YQ Lu - Scientific reports, 2020 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) has been spreading worldwide. Severe
cases quickly progressed with unfavorable outcomes. We aim to investigate the clinical …

Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19

Y Liu, W Tan, H Chen, Y Zhu, L Wan, K Jiang… - BMC infectious …, 2021 - Springer
Background The lack of knowledge regarding the pathogenesis and host immune response
during SARS-CoV-2 infection has limited the development of effective treatments. Thus, we …

T cell activation, highly armed cytotoxic cells and a shift in monocytes CD300 receptors expression is characteristic of patients with severe COVID-19

O Zenarruzabeitia, G Astarloa-Pando, I Terren… - Frontiers in …, 2021 - frontiersin.org
COVID-19 manifests with a wide diversity of clinical phenotypes characterized by
dysfunctional and exaggerated host immune responses. Many results have been described …

Immunologic features in coronavirus disease 2019: functional exhaustion of T cells and cytokine storm

S Mahmoudi, M Rezaei, N Mansouri, M Marjani… - Journal of clinical …, 2020 - Springer
To the Editor: Since the emergence of Coronavirus Disease 2019 (COVID-19) caused by the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, the …