Thiosemicarbazone Cu (II) and Zn (II) complexes as potential anticancer agents: Syntheses, crystal structure, DNA cleavage, cytotoxicity and apoptosis induction …

J Shao, ZY Ma, A Li, YH Liu, CZ Xie, ZY Qiang… - Journal of Inorganic …, 2014 - Elsevier
Four novel thiosemicarbazone metal complexes,[Cu (Am4M)(OAc)]· H 2 O (1),[Zn (HAm4M)
Cl 2](2),[Zn 2 (Am4M) 2 Br 2](3) and [Zn 2 (Am4M) 2 (OAc) 2]· 2MeOH (4)[HAm4M=(Z)-2 …

Synthesis, X-ray structure and in vitro cytotoxicity studies of Cu (I/II) complexes of thiosemicarbazone: special emphasis on their interactions with DNA

A Chakraborty, SP Dash, AK Panda, R Acharyya… - Dalton …, 2015 - pubs.rsc.org
4-(pX-phenyl) thiosemicarbazone of napthaldehyde {where X= Cl (HL1) and X= Br (HL2)},
thiosemicarbazone of quinoline-2-carbaldehyde (HL3) and 4-(p-fluorophenyl) …

Synthesis, antiproliferative activity and mechanism of copper (II)-thiosemicarbazone complexes as potential anticancer and antimicrobial agents

J Qi, X Wang, T Liu, M Kandawa-Schulz… - Journal of …, 2020 - Taylor & Francis
Malignant tumors have become one of the challenges to global human health today, and the
development of new drugs has become a research hotspot for tumor treatment. In order to …

Designing anticancer copper (II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands

J Deng, P Yu, Z Zhang, J Wang, J Cai, N Wu… - European Journal of …, 2018 - Elsevier
To develop potential next-generation metal anticancer agents, we designed and
synthesised five Cu (II) 2-pyridine-thiosemicarbazone complexes by modifying the hydrogen …

Thiosemicarbazone (s)-anchored water soluble mono-and bimetallic Cu (II) complexes: Enzyme-like activities, biomolecular interactions, anticancer property and real …

N Balakrishnan, J Haribabu, AK Dhanabalan… - Dalton …, 2020 - pubs.rsc.org
The reactions of CuCl2· 2H2O with chromone thiosemicarbazone ligands containing a–H or–
CH3 substituent on terminal N yielded monometallic Cu (II) complexes [Cu (HL1) Cl2](1) and …

Cu (II) and Zn (II) complexes from a thiosemicarbazone derivative: Investigating the intermolecular interactions, crystal structures and cytotoxicity

NA Mathews, JM Jacob, PMS Begum… - Journal of Molecular …, 2020 - Elsevier
Two complexes of Cu (II) and Zn (II) were prepared from a thiosemicarbazone derivative (H
2 esct) using their corresponding metal acetates and 2, 2′-bipyridine as base. The …

In vitro biomolecular interaction studies and cytotoxic activities of copper (II) and zinc (II) complexes bearing ONS donor thiosemicarbazones

NA Mathews, MRP Kurup - Applied Organometallic Chemistry, 2021 - Wiley Online Library
Among all the bio‐metals, zinc and copper derivatives of ONS donor thiosemicarbazone
have aroused great interest because of their potential biological applications …

Synthesis, characterization and antitumor activity of polymeric copper (II) complexes with thiosemicarbazones of 3-methyl-5-oxo-1-phenyl-3-pyrazolin-4 …

VM Leovac, GA Bogdanović, LS Jovanović… - Journal of Inorganic …, 2011 - Elsevier
New polymeric copper (II) complexes with two tridentate ONS thiosemicarbazone ligands
containing substituted pyrazolone moiety were synthesized and characterized by means of …

Synthesis, X-ray crystal structure, DNA/protein binding, DNA cleavage and cytotoxicity studies of N (4) substituted thiosemicarbazone based copper (II)/nickel (II) …

M Muralisankar, J Haribabu, NSP Bhuvanesh… - Inorganica Chimica …, 2016 - Elsevier
Abstract N-ethyl-2-(phenyl (pyridin-2-yl) methylene) hydrazinecarbothioamide (HBpyeTsc)
was obtained from 4-ethyl-3-thiosemicarbazide and 2-benzoylpyridine. The complexes …

Synthesis and crystal structure of new monometallic and bimetallic copper (II) complexes with N-substituted isatin thiosemicarbazone ligands: Effects of the complexes …

M Muralisankar, S Sujith, NSP Bhuvanesh… - Polyhedron, 2016 - Elsevier
A novel series of N-substituted isatin thiosemicarbazone ligands (L1–L3) and their copper
(II) complexes [Cu (II)(ITSC)] were synthesized and characterized by elemental analyses …