Genetic architectures of psychiatric disorders: the emerging picture and its implications

PF Sullivan, MJ Daly, M O'donovan - Nature Reviews Genetics, 2012 - nature.com
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …

[PDF][PDF] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders

PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
Studies of the genetics of psychiatric disorders have become one of the most exciting and
fast-moving areas in human genetics. A decade ago, there were few reproducible findings …

Recent progress in psychiatric genetics—some hope but no hype

SF Stoltenberg, M Burmeister - Human molecular genetics, 2000 - academic.oup.com
The reputation of the field of psychiatric genetics has recently become tarnished in the view
of many human geneticists. Too many linked loci were claimed and withdrawn, too many …

Psychiatric genetics and the structure of psychopathology

JW Smoller, OA Andreassen, HJ Edenberg… - Molecular …, 2019 - nature.com
For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Assessing the evidence for shared genetic risks across psychiatric disorders and traits

J Martin, MJ Taylor, P Lichtenstein - Psychological medicine, 2018 - cambridge.org
Genetic influences play a significant role in risk for psychiatric disorders, prompting
numerous endeavors to further understand their underlying genetic architecture. In this …

Psychiatric genetics: progress amid controversy

M Burmeister, MG McInnis, S Zöllner - Nature Reviews Genetics, 2008 - nature.com
Several psychiatric disorders—such as bipolar disorder, schizophrenia and autism—are
highly heritable, yet identifying their genetic basis has been challenging, with most …

What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn

KS Kendler - Molecular psychiatry, 2013 - nature.com
Psychiatric genetics has taught us a great deal about the nature of psychiatric disorders.
Traditional family, twin and adoption studies have demonstrated the substantial role of …

Emerging phenotyping strategies will advance our understanding of psychiatric genetics

S Sanchez-Roige, AA Palmer - Nature neuroscience, 2020 - nature.com
Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …

Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice

JL Doherty, MJ Owen - Genome medicine, 2014 - Springer
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder,
attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result …