Splicing noncoding RNAs from the inside out

L Yang - Wiley Interdisciplinary Reviews: RNA, 2015 - Wiley Online Library
Eukaryotic precursor‐messenger RNAs (pre‐mRNAs) undergo splicing to remove intragenic
regions (introns) and ligate expressed regions (exons) together. Unlike exons in the mature …

The reciprocal regulation between splicing and 3′‐end processing

D Kaida - Wiley Interdisciplinary Reviews: RNA, 2016 - Wiley Online Library
Most eukaryotic precursor mRNAs are subjected to RNA processing events, including 5′‐
end capping, splicing and 3′‐end processing. These processing events were historically …

Intronic RNA: Ad 'junk'mediator of post-transcriptional gene regulation

CR Neil, WG Fairbrother - Biochimica et Biophysica Acta (BBA)-Gene …, 2019 - Elsevier
RNA splicing, the process through which intervening segments of noncoding RNA (introns)
are excised from pre-mRNAs to allow for the formation of a mature mRNA product, has long …

Exploring the alternative splicing of long noncoding RNAs

MR Khan, RJ Wellinger, B Laurent - Trends in Genetics, 2021 - cell.com
Like protein-coding genes, long noncoding RNA (lncRNA) genes are composed of introns
and exons. After their transcription, lncRNAs are subject to constitutive and/or alternative …

Mutually exclusive alternative splicing of pre‐mRNAs

Y Jin, H Dong, Y Shi, L Bian - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Pre‐mRNA alternative splicing is an important mechanism used to expand protein diversity
in higher eukaryotes, and mutually exclusive splicing is a specific type of alternative splicing …

Unscrambling genetic information at the RNA level

S Moreira, S Breton, G Burger - Wiley Interdisciplinary Reviews …, 2012 - Wiley Online Library
Genomics aims at unraveling the blueprint of life; however, DNA sequence alone does not
always reveal the proteins and structural RNAs encoded by the genome. The reason is that …

Inefficient splicing of long non-coding RNAs is associated with higher transcript complexity in human and mouse

K Basu, A Dey, M Kiran - RNA biology, 2023 - Taylor & Francis
Recent reports show that long non-coding RNAs (lncRNAs) have inefficient splicing and
fewer alternative splice variants than mRNAs. Here, we have explored the efficiency of …

Splicing regulation by long noncoding RNAs

N Romero-Barrios, MF Legascue… - Nucleic acids …, 2018 - academic.oup.com
Massive high-throughput sequencing techniques allowed the identification of thousands of
noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in …

The splicing code goes deep

S Bao, DF Moakley, C Zhang - Cell, 2019 - cell.com
The Splicing Code Goes Deep: Cell Skip to Main Content Advertisement Cell This journal
offers authors two options (open access or subscription) to publish research Submit Log in …

From single splicing events to thousands: the ambiguous step forward in splicing research

E Buratti, M Baralle, FE Baralle - Briefings in functional …, 2013 - academic.oup.com
Since the discovery of RNA splicing in 1977 the knowledge of this important biological
process has increased steadily following the identification of many of the mechanistic …