Background Polygenic risk score (PRS) analyses have become an integral part of
biomedical research, exploited to gain insights into shared aetiology among traits, to control …

Major psychiatric disorders are heritable but they are genetically complex. This means that,
with certain exceptions, single gene markers will not be helpful for diagnosis. However, we …

Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide
polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed …

Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating
health disparities. We propose PolyPred, a method that improves cross-population …

We present a systematic assessment of polygenic risk score (PRS) prediction across more
than 1,500 traits using genetic and phenotype data in the UK Biobank. We report 813 sparse …

Fields as diverse as human genetics and sociology are increasingly using polygenic scores
based on genome-wide association studies (GWAS) for phenotypic prediction. However …