Malaria parasites utilize Methylerythritol phosphate (MEP) pathway for synthesis of
isoprenoid precursors which are essential for maturation and survival of parasites during …

Abstract The prokaryotic type Methyl Erythritol phosphate (MEP) pathway functional in the
apicoplast of Plasmodium is indispensable for the erythrocytic stages of the parasite. It is the …

Malaria is one of the leading parasitic diseases to humans caused by Plasmodium
falciparum. It is imperative to discover novel targets for the development of antimalarial …

In most of the pathogenic organisms including Plasmodium falciparum, isoprenoids are
synthesized via MEP (MethylErythritol 4-Phosphate) pathway. LytB is the last enzyme of this …

The methylerythritol phosphate (MEP) pathway of Plasmodium falciparum (P. falciparum)
has become an attractive target for anti-malarial drug discovery. This study describes a …

Biosynthesis of isoprenoids (MEP Pathway) in apicoplast has an important role during the
erythrocytic stages of Plasmodium, as it is the sole pathway to provide the major isoprene …

As resistance to current therapies spreads, novel antimalarials are urgently needed. In this
work, we examine the potential for therapeutic intervention via the targeting of Plasmodium …

Malaria parasite harbors an essential prokaryotic-like organelle characterized by multiple
mem-branes, akin to a plastid. This organelle, known as the apicoplast, evolved from …

The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …

We identified MMV026468 as a picomolar inhibitor of blood-stage Plasmodium falciparum.
Phenotyping assays, including isopentenyl diphosphate rescue of parasite growth inhibition …