Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

L Du, W Tai, Y Yang, G Zhao, Q Zhu, S Sun… - Nature …, 2016 - nature.com
Viral subunit vaccines often contain immunodominant non-neutralizing epitopes that divert
host immune responses. These epitopes should be eliminated in vaccine design, but there …

Evaluation of candidate vaccine approaches for MERS-CoV

L Wang, W Shi, MG Joyce, K Modjarrad… - Nature …, 2015 - nature.com
Abstract The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) as a
cause of severe respiratory disease highlights the need for effective approaches to CoV …

Current advancements and potential strategies in the development of MERS-CoV vaccines

N Zhang, S Jiang, L Du - Expert review of vaccines, 2014 - Taylor & Francis
Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by
a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of β …

Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein

L Jiang, N Wang, T Zuo, X Shi, KMV Poon… - Science translational …, 2014 - science.org
The recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) causes
severe and fatal acute respiratory illness in humans. However, no prophylactic and …

DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice

H Chi, X Zheng, X Wang, C Wang, H Wang, W Gai… - Vaccine, 2017 - Elsevier
Abstract The Middle East respiratory syndrome coronavirus (MERS-CoV), is an emerging
pathogen that continues to cause outbreaks in the Arabian peninsula and in travelers from …

Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus

Y Deng, J Lan, L Bao, B Huang, F Ye… - Emerging Microbes & …, 2018 - Taylor & Francis
The persistent public health threat of infection with Middle East respiratory syndrome
coronavirus (MERS-CoV) highlights the need for an effective and safe MERS-CoV vaccine …

MERS coronavirus outbreak: Implications for emerging viral infections

A Al-Omari, AA Rabaan, S Salih, JA Al-Tawfiq… - … and infectious disease, 2019 - Elsevier
In September 2012, a novel coronavirus was isolated from a patient who died in Saudi
Arabia after presenting with acute respiratory distress and acute kidney injury. Analysis …

MERS coronavirus: an emerging zoonotic virus

F Li, L Du - Viruses, 2019 - mdpi.com
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus that was
first reported in humans in June 2012 [1]. To date, MERS-CoV continues to infect humans …

Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein

A Fukuma, H Tani, S Taniguchi, M Shimojima… - Archives of …, 2015 - Springer
Middle East respiratory syndrome (MERS) coronavirus (Co-V) contains a single spike (S)
protein, which binds to a receptor molecule, dipeptidyl peptidase 4 (DPP4; also known as …

A novel human mAb (MERS-GD27) provides prophylactic and postexposure efficacy in MERS-CoV susceptible mice

P Niu, G Zhao, Y Deng, S Sun, W Wang… - Science China. Life …, 2018 - search.proquest.com
Since September 2012, the Middle East respiratory syndrome coronavirus (MERS-CoV)
cases have been reported in more than 27 countries, and more than 2,000 cases have been …