A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus …

G Zhao, L Du, C Ma, Y Li, L Li, VKM Poon, L Wang… - Virology journal, 2013 - Springer
Background Evidence points to the emergence of a novel human coronavirus, Middle East
respiratory syndrome coronavirus (MERS-CoV), which causes a severe acute respiratory …

[HTML][HTML] Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia

S Kasem, I Qasim, A Al-Hufofi, O Hashim… - Journal of infection and …, 2018 - Elsevier
Abstract Background Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly
emerged coronavirus that is associated with a severe respiratory disease in humans in the …

Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein

I Widjaja, C Wang, R van Haperen… - Emerging microbes & …, 2019 - Taylor & Francis
ABSTRACT The Middle-East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic
virus that causes severe and often fatal respiratory disease in humans. Efforts to develop …

Recent advances in the vaccine development against Middle East respiratory syndrome-coronavirus

CY Yong, HK Ong, SK Yeap, KL Ho… - Frontiers in microbiology, 2019 - frontiersin.org
Middle East respiratory syndrome (MERS) is a deadly viral respiratory disease caused by
MERS-coronavirus (MERS-CoV) infection. To date, there is no specific treatment proven …

Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious Diseases

J Shi, J Zhang, S Li, J Sun, Y Teng, M Wu, J Li, Y Li… - PloS one, 2015 - journals.plos.org
Middle East respiratory syndrome coronavirus (MERS-CoV) with pandemic potential is a
major worldwide threat to public health. However, vaccine development for this pathogen …

Recombinant receptor-binding domains of multiple Middle East respiratory syndrome coronaviruses (MERS-CoVs) induce cross-neutralizing antibodies against …

W Tai, Y Wang, CA Fett, G Zhao, F Li… - Journal of …, 2017 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) binds to cellular receptor
dipeptidyl peptidase 4 (DPP4) via the spike (S) protein receptor-binding domain (RBD). The …

Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein

J Rodon, NMA Okba, N Te, B van Dieren… - Emerging microbes & …, 2019 - Taylor & Francis
ABSTRACT The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV)
outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission …

Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice

E Kim, K Okada, T Kenniston, VS Raj, MM AlHajri… - Vaccine, 2014 - Elsevier
A new type of coronavirus has been identified as the causative agent underlying Middle East
Respiratory Syndrome (MERS). The MERS coronavirus (MERS-CoV) has spread in the …

Molecular evolution of MERS coronavirus: dromedaries as a recent intermediate host or long-time animal reservoir?

SKP Lau, ACP Wong, TCK Lau, PCY Woo - International Journal of …, 2017 - mdpi.com
While dromedary camels are the immediate animal source of MERS coronavirus (MERS-
CoV) infection, the evolutionary origin of MERS-CoV remains obscure. We analyzed 219 …

Advances in MERS-CoV vaccines and therapeutics based on the receptor-binding domain

Y Zhou, Y Yang, J Huang, S Jiang, L Du - Viruses, 2019 - mdpi.com
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus
that was first reported in 2012. The MERS-CoV genome encodes four major structural …