A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

K Muthumani, D Falzarano, EL Reuschel… - Science translational …, 2015 - science.org
First identified in 2012, Middle East respiratory syndrome (MERS) is caused by an emerging
human coronavirus, which is distinct from the severe acute respiratory syndrome …

Ultrapotent human neutralizing antibody repertoires against Middle East respiratory syndrome coronavirus from a recovered patient

P Niu, S Zhang, P Zhou, B Huang… - The Journal of …, 2018 - academic.oup.com
Abstract Background The Middle East respiratory syndrome coronavirus (MERS-CoV)
causes severe respiratory infection with a high (~ 35%) mortality rate. Neutralizing …

MERS coronavirus: diagnostics, epidemiology and transmission

IM Mackay, KE Arden - Virology journal, 2015 - Springer
The first known cases of Middle East respiratory syndrome (MERS), associated with infection
by a novel coronavirus (CoV), occurred in 2012 in Jordan but were reported retrospectively …

Efficacy of an adjuvanted Middle East respiratory syndrome coronavirus spike protein vaccine in dromedary camels and alpacas

DR Adney, L Wang, N Van Doremalen, W Shi, Y Zhang… - Viruses, 2019 - mdpi.com
MERS-CoV is present in dromedary camels throughout the Middle East and Africa.
Dromedary camels are the primary zoonotic reservoir for human infections. Interruption of …

Tailoring subunit vaccine immunity with adjuvant combinations and delivery routes using the Middle East respiratory coronavirus (MERS-CoV) receptor-binding …

J Lan, Y Deng, H Chen, G Lu, W Wang, X Guo, Z Lu… - PloS one, 2014 - journals.plos.org
The development of an effective vaccine is critical for prevention of a Middle East respiratory
syndrome coronavirus (MERS-CoV) pandemic. Some studies have indicated the receptor …

Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China

W Wang, H Wang, Y Deng, T Song, J Lan… - Emerging Microbes & …, 2016 - Taylor & Francis
The first imported case of Middle East respiratory syndrome (MERS) in China recently
occurred, allowing for the characterization of antibody titers in a series of the patient's sera …

MERS-CoV: epidemiology, molecular dynamics, therapeutics, and future challenges

AA Rabaan, SH Al-Ahmed, R Sah… - Annals of Clinical …, 2021 - Springer
Abstract The Severe Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has gained
research attention worldwide, given the current pandemic. Nevertheless, a previous …

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

J Pallesen, N Wang, KS Corbett… - Proceedings of the …, 2017 - National Acad Sciences
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus
that since its emergence in 2012 has caused outbreaks in human populations with case …

COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics

K Dhama, K Sharun, R Tiwari, M Dadar… - Human vaccines & …, 2020 - Taylor & Francis
The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from
Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been …

Heterologous prime–boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory …

SY Jung, KW Kang, EY Lee, DW Seo, HL Kim, H Kim… - Vaccine, 2018 - Elsevier
Abstract The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly
pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several …