Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets

E de Wit, F Feldmann, A Okumura, E Horne, E Haddock… - Antiviral research, 2018 - Elsevier
The high case-fatality rate of confirmed MERS-CoV infections underlines the urgent need for
an effective treatment to reduce the disease severity and mortality. REGN3051 and …

[HTML][HTML] Middle East respiratory syndrome coronavirus vaccines: current status and novel approaches

NMA Okba, VS Raj, BL Haagmans - Current opinion in virology, 2017 - Elsevier
Highlights•MERS-CoV vaccines for dromedary camels and their human contacts can
potentially stop virus transmission in the community.•Both neutralizing antibody and T-cell …

Structural definition of a neutralization-sensitive epitope on the MERS-CoV S1-NTD

N Wang, O Rosen, L Wang, HL Turner, LJ Stevens… - Cell reports, 2019 - cell.com
Middle East respiratory syndrome coronavirus (MERS-CoV) emerged into the human
population in 2012 and has caused substantial morbidity and mortality. Potently neutralizing …

Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels

NK Alharbi, I Qasim, A Almasoud, HA Aljami… - Scientific reports, 2019 - nature.com
MERS-CoV seronegative and seropositive camels received a single intramuscular dose of
ChAdOx1 MERS, a replication-deficient adenoviral vectored vaccine expressing MERS-CoV …

MERS-CoV: understanding the latest human coronavirus threat

A Chafekar, BC Fielding - Viruses, 2018 - mdpi.com
Human coronaviruses cause both upper and lower respiratory tract infections in humans. In
2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe …

Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates

C Selinger, J Tisoncik-Go, VD Menachery… - BMC genomics, 2014 - Springer
Background The recent emergence of a novel coronavirus in the Middle East (designated
MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging …

Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies

F Song, R Fux, LB Provacia, A Volz… - Journal of …, 2013 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) has recently emerged as a
causative agent of severe respiratory disease in humans. Here, we constructed recombinant …

Development and validation of different indirect ELISAs for MERS-CoV serological testing

AM Hashem, SS Al-Amri, TL Al-Subhi, LA Siddiq… - Journal of …, 2019 - Elsevier
Since 2012, MERS-CoV has caused up to 2220 cases and 790 deaths in 27 countries with
Saudi Arabia being the most affected country with~ 83.1% of the cases and~ 38.8% local …

Protective efficacy of recombinant modified vaccinia virus Ankara delivering Middle East respiratory syndrome coronavirus spike glycoprotein

A Volz, A Kupke, F Song, S Jany, R Fux… - Journal of …, 2015 - Am Soc Microbiol
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory
disease in humans. We tested a recombinant modified vaccinia virus Ankara (MVA) vaccine …

Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus

N Zhang, R Channappanavar, C Ma, L Wang… - Cellular & molecular …, 2016 - nature.com
Middle East respiratory syndrome (MERS), an emerging infectious disease caused by
MERS coronavirus (MERS-CoV), has garnered worldwide attention as a consequence of its …