MJ Berna, O Seiz, JF Nast, D Benten, M Bläker… - Journal of Biological …, 2010 - ASBMB
The gastrointestinal hormone cholecystokinin (CCK) can induce acute pancreatitis in rodents through its action on acinar cells. Treatment with CCK, in combination with other …
JP Smith, TK Cooper, CO McGovern, EL Gilius… - Pancreas, 2014 - journals.lww.com
Objectives Exogenous administration of cholecystokinin (CCK) induces hypertrophy and hyperplasia of the pancreas with an increase in DNA content. We hypothesized that …
Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …
ZX Malchiodi, H Cao, MD Gay, A Safronenka, S Bansal… - Cancers, 2021 - mdpi.com
Simple Summary Our research team has identified the cholecystokinin-B receptor (or CCK- BR) as a novel target for treatment of pancreatic cancer. CCK-BRs are over-expressed in …
Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction. It is now known that pancreatic stellate cells (PSCs) are the principal source of fibrosis in the stroma …
H Habisch, S Zhou, M Siech, MG Bachem - Cancers, 2010 - mdpi.com
Pancreatic cancer is characterized by its late detection, aggressive growth, intense infiltration into adjacent tissue, early metastasis, resistance to chemo-and radiotherapy and …
Tumour-stromal interactions have now been acknowledged to play a major role in pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …
Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile molecular behavior and complex tumor microenvironment. It has been recently postulated …
A Karger, B Fitzner, P Brock, G Sparmann, J Emmrich… - Cellular signalling, 2008 - Elsevier
Pancreatic fibrosis, a key feature of chronic pancreatitis and pancreatic cancer, is mediated by activated pancreatic stellate cells (PSC). Connective tissue growth factor (CTGF) has …