Since conventional and targeted therapies aiming at cancer cells have largely failed to
prolong survival in pancreatic cancer, targeting the infrastructure of the tumor, hence its …

Pancreatic stellate cells (PSC) are the key cells responsible for fibrogenesis in the pancreas.
In health, PSC maintain a fine balance between ECM production and degradation, thereby …

Pancreatic cancer occurs in the setting of a profound fibrotic microenvironment that often
dwarfs the actual tumor. Although pancreatic fibrosis has been well studied in chronic …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

Pancreatic stellate cells are stromal cells that have multiple physiological functions such as
the production of extracellular matrix, stimulation of amylase secretion, phagocytosis and …

While the morphology and function of cells of the exocrine and endocrine pancreas have
been studied over several centuries, one important cell type in the gland, the pancreatic …

Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is
characterized by an expanded stroma with marked fibrosis (desmoplasia). We previously …

The stroma is a main driver of metastasis and aggressiveness in pancreatic cancer (PC),
one of the deadliest malignancies worldwide. Pancreatic stellate cells (PSCs) form …

Activated pancreatic stellate cells (PSCs) are the main effector cells in the process of
fibrosis, a major pathological feature in pancreatic diseases that including chronic …

Stromal-tumor interactions in pancreatic cancer (PC) impact on treatment outcomes.
Pancreatic stellate cells (PSCs) produce the collagenous stroma of PC and interact with …