Within the gastrointestinal stem cell niche, nerves help to regulate both normal and
neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer …

The nervous system plays an important role in the regulation of epithelial homeostasis and
has also been postulated to play a role in tumorigenesis. We provide evidence that proper …

Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted
processes within the highly complex and dynamic ecosystem of the gastrointestinal tract …

Regulated antimicrobial peptide expression in the intestinal epithelium is key to defense
against infection and to microbiota homeostasis. Understanding the mechanisms that …

The major signaling pathways regulating gastric stem cells are unknown. Here we report
that Notch signaling is essential for homeostasis of LGR 5+ antral stem cells. Pathway …

Colorectal cancer stem cells (CSCs) contribute to colorectal tumorigenesis and metastasis.
Colorectal CSCs reside within specialized niches and harbor self-renewal and …

In this review, we highlight recent discoveries regarding mechanisms contributing to nerve-
cancer cross-talk and the effects of nerve-cancer cross-talk on tumor progression and …

Recent evidences show that nervous system acts as a crucial part of cancer
microenvironment. Infiltration of nerve fibers into cancer microenvironment has an important …

The mammalian adult gastric epithelium self-renews continually through the activity of stem
cells located in the isthmus of individual gland units. Mechanisms facilitating stomach stem …

The cellular origin of digestive cancers has been a long-standing question in the cancer
field. Mouse models have identified long-lived stem cells in most organ systems, including …