Diabetic Endothelial Cell Glycogen Synthase Kinase 3β Activation Induces VCAM1 Ectodomain Shedding

MA Brishti, S Raghavan, K Lamar, UP Singh… - International Journal of …, 2023 - mdpi.com
Soluble cell adhesion molecules (sCAMs) are secreted ectodomain fragments of surface
adhesion molecules, ICAM1 and VCAM1. sCAMs have diverse immune functions beyond …

[HTML][HTML] VCAM-1 as a predictor biomarker in cardiovascular disease

MF Troncoso, J Ortiz-Quintero… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The vascular cellular adhesion molecule-1 (VCAM-1) is a protein that canonically
participates in the adhesion and transmigration of leukocytes to the interstitium during …

Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3

RJR Singh, JC Mason, EA Lidington… - Cardiovascular …, 2005 - academic.oup.com
Objectives: Vascular cell adhesion molecule-1 (VCAM-1) is a cell surface adhesion
molecule involved in the recruitment of leukocytes to endothelial cells on arterial walls …

Targeting VCAM-1: a therapeutic opportunity for vascular damage

MF Troncoso, MC Díaz-Vesga… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The vascular cell adhesion molecule (VCAM-1) is a transmembrane
sialoglycoprotein detected in activated endothelial and vascular smooth muscle cells …

Elevated plasma levels of vascular cell adhesion molecule‐1 (VCAM‐1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive …

AM Schmidt, J Crandall, O Hori, R Cao… - British journal of …, 1996 - Wiley Online Library
Advanced glycation endproducts (AGEs), which accumulate in diabetic vasculature, result in
enhanced expression of endothelial cell‐associated vascular cell adhesion molecule‐1 …

Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1–directed novel …

JR Pickett, Y Wu, LF Zacchi, HT Ta - Cardiovascular Research, 2023 - academic.oup.com
Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical
contributor to atherosclerosis and consequently as an attractive therapeutic target for anti …

[HTML][HTML] Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes

J Wang, H Zhou, J Shao, S Zhang… - Diabetes & metabolism …, 2023 - synapse.koreamed.org
Background Dysfunction of vascular endothelial cells (ECs) plays a central role in the
pathogenesis of cardiovascular complications in diabetes. SWI/SNF-related matrix …

Soluble vascular cell adhesion molecule-1 (VCAM-1) as a biomarker in the mouse model of experimental autoimmune myocarditis (EAM)

U Grabmaier, G Kania, J Kreiner, J Grabmeier, A Uhl… - Plos one, 2016 - journals.plos.org
Vascular cell adhesion molecule-1 (VCAM-1) is strongly upregulated in hearts of mice with
coxsackie virus-induced as well as in patients with viral infection-triggered dilated …

Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage

HM Dansky, CB Barlow, C Lominska… - … , and vascular biology, 2001 - Am Heart Assoc
Vascular cell adhesion molecule-1 (VCAM-1/Vcam1) is a cytokine-inducible member of the
immunoglobulin gene superfamily that is expressed by arterial endothelial cells in regions …

Increased levels of soluble vascular cell adhesion molecule 1 are associated with risk of cardiovascular mortality in type 2 diabetes: the Hoorn study.

A Jager, VW Van Hinsbergh, PJ Kostense, JJ Emeis… - Diabetes, 2000 - Am Diabetes Assoc
Membrane-bound vascular cell adhesion molecule 1 (VCAM-1) allows the tethering and
rolling of monocytes and lymphocytes as well as firm attachment and transendothelial …