A high-throughput screen of the NIH molecular libraries sample collection and subsequent
optimization of a lead dipeptide-like series of severe acute respiratory syndrome (SARS) …

Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a
novel human coronavirus. Viral maturation requires a main protease (3CL pro) to cleave the …

The 3C-like proteinase of severe acute respiratory syndrome (SARS) coronavirus has been
proposed to be a key target for structural-based drug design against SARS. In order to …

Coronaviruses (CoVs) are positive single‐stranded RNA viruses that cause severe
respiratory syndromes in humans, including severe acute respiratory syndrome (SARS) and …

SARS (severe acute respiratory syndrome) is caused by a newly discovered coronavirus. A
key enzyme for the maturation of this virus and, therefore, a target for drug development is …

Although the initial outbreaks of the deadly coronavirus that causes severe acute respiratory
syndrome (SARS-CoV) were controlled by public health measures, the development of …

The 3C‐like protease of the severe acute respiratory syndrome (SARS) coronavirus has a C‐
terminal extra domain in addition to the chymotrypsin‐fold adopted by piconavirus 3C …

The 3C-like protease of SARS coronavirus (SARS-CoV 3CLpro) is vital for SARS-CoV
replication and is a promising drug target. It has been extensively proved that only the …

The SARS coronavirus main peptidase (SARS-CoV Mpro) plays an essential role in the life-
cycle of the virus and is a primary target for the development of anti-SARS agents. Here, we …

Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide
spectrum of diseases. The coronavirus main protease (Mpro), which plays a pivotal role in …