Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design
Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide
spectrum of diseases. The coronavirus main protease (Mpro), which plays a pivotal role in …
spectrum of diseases. The coronavirus main protease (Mpro), which plays a pivotal role in …
A Patent Review on SARS Coronavirus Main Protease (3CLpro) Inhibitors
CSB Chia, W Xu, P Shuyi Ng - ChemMedChem, 2022 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic is an
unprecedented global health emergency causing more than 4.2 million fatalities as of 30 …
unprecedented global health emergency causing more than 4.2 million fatalities as of 30 …
Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus,
DH Goetz, Y Choe, E Hansell, YT Chen… - Biochemistry, 2007 - ACS Publications
Severe acute respiratory syndrome (SARS) is an emerging infectious disease associated
with a high rate of mortality. The SARS-associated coronavirus (SARS-CoV) has been …
with a high rate of mortality. The SARS-associated coronavirus (SARS-CoV) has been …
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase
The causative agent of severe acute respiratory syndrome (SARS) has been identified as a
novel coronavirus, SARS-CoV. The main proteinase of SARS-CoV, 3CL pro, is an attractive …
novel coronavirus, SARS-CoV. The main proteinase of SARS-CoV, 3CL pro, is an attractive …
Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters
J Zhang, HI Pettersson, C Huitema, C Niu… - Journal of medicinal …, 2007 - ACS Publications
The 3C-like protease (3CLpro), which controls the severe acute respiratory syndrome
(SARS) coronavirus replication, has been identified as a potential target for drug design in …
(SARS) coronavirus replication, has been identified as a potential target for drug design in …
Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro
L Chen, C Gui, X Luo, Q Yang, S Günther… - Journal of …, 2005 - Am Soc Microbiol
ABSTRACT The 3C-like proteinase (3CLpro) of severe acute respiratory syndrome-
associated coronavirus (SARS-CoV) is one of the most promising targets for anti-SARS-CoV …
associated coronavirus (SARS-CoV) is one of the most promising targets for anti-SARS-CoV …
Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization: biochemical and …
Severe acute respiratory syndrome (SARS) coronavirus is a novel human coronavirus and is
responsible for SARS infection. SARS coronavirus 3C-like proteinase (SARS 3CL pro) plays …
responsible for SARS infection. SARS coronavirus 3C-like proteinase (SARS 3CL pro) plays …
Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS
In order to stimulate the development of drugs against severe acute respiratory syndrome
(SARS), based on the atomic coordinates of the SARS coronavirus main proteinase …
(SARS), based on the atomic coordinates of the SARS coronavirus main proteinase …
Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
L Zhu, S George, MF Schmidt, SI Al-Gharabli… - Antiviral research, 2011 - Elsevier
SARS coronavirus main protease (SARS-CoV Mpro) is essential for the replication of the
virus and regarded as a major antiviral drug target. The enzyme is a cysteine protease, with …
virus and regarded as a major antiviral drug target. The enzyme is a cysteine protease, with …
Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV
H Lee, H Lei, BD Santarsiero, JL Gatuz… - ACS chemical …, 2015 - ACS Publications
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) papain-like protease
(PLpro) blocking loop 2 (BL2) structure differs significantly from that of SARS-CoV PLpro …
(PLpro) blocking loop 2 (BL2) structure differs significantly from that of SARS-CoV PLpro …