Understanding the earliest molecular and cellular events associated with cancer initiation
remains a key bottleneck to transforming our approach to cancer prevention and detection …

Reproduced from https://visualsonline. cancer. gov/details. cfm? imageid= 11474. Early
detection offers a better chance of saving lives from cancer. The National Cancer Institute …

Many cancers evolve from benign precancerous lesions and have a natural history of
progression that provides a window of opportunity for intervention. The biological …

Summary The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of
diverse genomic alterations underlying human cancers. At this historic junction marking the …

Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …

Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …

The hallmarks of premalignant lesions were first described in the 1970s, a time when
relatively little was known about the molecular underpinnings of cancer. Yet it was clear …

Despite improvements in the understanding of cancer causation, much remains unknown
regarding the mechanisms by which genomic and non-genomic factors initiate …

Abstract The Cancer Genome Atlas (TCGA) represents one of several international consortia
dedicated to performing comprehensive genomic and epigenomic analyses of selected …

Advances in high-throughput, genome-wide profiling technologies have allowed for an
unprecedented view of the cancer genome landscape. Specifically, high-density microarrays …