Glutamate networks implicate cognitive impairments in schizophrenia: genome-wide association studies of 52 cognitive phenotypes
K Ohi, R Hashimoto, M Ikeda, H Yamamori… - Schizophrenia …, 2015 - academic.oup.com
Cognitive impairments are a core feature in patients with schizophrenia. These deficits could
serve as effective tools for understanding the genetic architecture of schizophrenia. This …
serve as effective tools for understanding the genetic architecture of schizophrenia. This …
A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis
Schizophrenia is an illness characterized by positive symptoms, negative symptoms, and
cognitive impairments. Cognitive impairments occur before the onset of psychosis and could …
cognitive impairments. Cognitive impairments occur before the onset of psychosis and could …
A Polygenic Risk Score of glutamatergic SNPs associated with schizophrenia predicts attentional behavior and related brain activity in healthy humans
A Rampino, P Taurisano, G Fanelli, M Attrotto… - European …, 2017 - Elsevier
Multiple genetic variations impact on risk for schizophrenia. Recent analyses by the
Psychiatric Genomics Consortium (PGC2) identified 128 SNPs genome-wide associated …
Psychiatric Genomics Consortium (PGC2) identified 128 SNPs genome-wide associated …
[HTML][HTML] Genetic overlap between general cognitive function and schizophrenia: a review of cognitive GWASs
General cognitive (intelligence) function is substantially heritable, and is a major
determinant of economic and health-related life outcomes. Cognitive impairments and …
determinant of economic and health-related life outcomes. Cognitive impairments and …
The genetics of cognitive impairment in schizophrenia: a phenomic perspective
Cognitive impairments are central to schizophrenia and could mark underlying biological
dysfunction but efforts to detect genetic associations for schizophrenia or cognitive …
dysfunction but efforts to detect genetic associations for schizophrenia or cognitive …
A transcriptome-wide association study implicates specific pre-and post-synaptic abnormalities in schizophrenia
Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
[HTML][HTML] Interactome overlap between schizophrenia and cognition
Cognitive impairments constitute a core feature of schizophrenia, and a genetic overlap
between schizophrenia and cognitive functioning in healthy individuals has been identified …
between schizophrenia and cognitive functioning in healthy individuals has been identified …
[HTML][HTML] Risk-conferring glutamatergic genes and brain glutamate plus glutamine in schizophrenia
JR Bustillo, V Patel, T Jones, R Jung… - Frontiers in …, 2017 - frontiersin.org
Background The proton magnetic resonance spectroscopy (1H-MRS) signals from
glutamate (or the combined glutamate and glutamine signal—Glx) have been found to be …
glutamate (or the combined glutamate and glutamine signal—Glx) have been found to be …
[HTML][HTML] Polygenic risk scores shed light on the relationship between schizophrenia and cognitive functioning: review and meta-analysis
Schizophrenia is a multifactorial disease associated with widespread cognitive impairment.
Although cognitive deficits are one of the factors most strongly associated with functional …
Although cognitive deficits are one of the factors most strongly associated with functional …
Identification of genetic loci jointly influencing schizophrenia risk and the cognitive traits of verbal-numerical reasoning, reaction time, and general cognitive function
Importance Schizophrenia is associated with widespread cognitive impairments. Although
cognitive deficits are one of the factors most strongly associated with functional outcome in …
cognitive deficits are one of the factors most strongly associated with functional outcome in …