Improved Radical Approach to N‐Unsubstituted Indol‐2‐one and Dihydro‐2‐quinolinone Compounds Bearing Spirocyclic Cyclohexanone/Cyclohexadienone Rings

T Lanza, M Minozzi, A Monesi, D Nanni… - Advanced Synthesis …, 2010 - Wiley Online Library
Abstract N‐Unsubstituted indol‐2‐one and 3, 4‐dihydro‐2‐quinolinone compounds bearing
spirocyclic cyclohexanone/cyclohexadienone rings can be accessed through a novel …

Synthesis of 4‐Quinolones: N,O‐Bis(trimethylsilyl)acetamide‐Mediated Cyclization with Cleavage of Aromatic C–O Bond

O Píša, S Rádl - European Journal of Organic Chemistry, 2016 - Wiley Online Library
Abstract The synthesis of 1, 4‐dihydro‐4‐oxoquinoline derivatives (4‐quinolones) based on
a BSA [N, O‐bis (trimethylsilyl) acetamide]‐mediated cyclization of substituted 1‐(2 …

Na2S2O8‐Promoted Radical Cyclization for the Synthesis of Azaspiro[4.5]deca‐3,6,9‐triene‐2,8‐dione and Pyrrolo[2,1‐j]quinolone Derivatives

CR Reddy, S Yarlagadda, B Ramesh… - European Journal of …, 2017 - Wiley Online Library
An efficient radical cyclization of N‐(4‐methoxyphenyl)‐N‐methyl‐3‐phenylpropiolamides
with 1‐phenylcyclopropan‐1‐ols has been developed using Na2S2O8 to produce azaspiro …

Radical Deaminative ipso-Cyclization of 4-Methoxyanilines with 1,7-Enynes for Accessing Spirocyclohexadienone-Containing Cyclopenta[c]quinolin-4-ones

J Li, WW Zhang, XJ Wei, F Liu, WJ Hao… - The Journal of …, 2017 - ACS Publications
A new C-center radical-triggered bicyclization cascade of N-tethered 1, 7-enynes for forming
28 examples of biologically interesting spirocyclohexadienone-containing cyclopenta [c] …

Synthesis of 2, 3-di (ω-hydroxyalkyl) quinolines from anilines and cyclic enols using sequential cycloaddition/aromatization reactions

CMM Gómez, M Marsiglia, R Escarsena, E del Olmo… - Tetrahedron …, 2018 - Elsevier
A new synthetic protocol for the one-pot synthesis of 2-(4-hydroxybutyl)-3-(3-hydroxypropyl)
quinolines and 3-(2-hydroxyethyl)-2-(3-hydroxypropyl)-quinolines based in the AB 2 imino …

Hydroxyalkylation-Initiated Radical Cyclization of N-Allylbenzamide for Direct Construction of Isoquinolinone

W Zhou, S Ni, H Mei, J Han, Y Pan - Organic letters, 2015 - ACS Publications
A metal-free hydroxyalkylation-initiated radical six-membered heterocycle formation reaction
of N-allylbenzamide is developed. This reaction proceeds through C (sp3)–H bond …

Approach to spirocyclohexadienimines and corresponding dienones through radical ipso cyclization onto aromatic azides.

T Lanza, R Leardini, M Minozzi, D Nanni… - ANGEWANDTE …, 2008 - cris.unibo.it
Cyclization of aryl radicals at the ipso-position of p-azido-substituted benzamides or 2-
(phenyl) acetamides results in effective production of spirocyclohexadieniminyl radicals …

The tandem reaction combining radical and ionic processes: an efficient approach to substituted 3, 4-dihydroquinolin-2-ones

W Zhou, L Zhang, N Jiao - Tetrahedron, 2009 - Elsevier
3, 4-Dihydroquinolin-2-ones are of great importance in the areas of pharmaceuticals.
However, the direct intramolecular radical cyclizations of the corresponding amide …

Synthesis of 3, 4-dihydrobenzo [g] isoquinoline-1 (2H)-ones and 3, 4-dihydroisoquinoline-1 (2H)-ones skeleton via intramolecular electrophilic cyclization

MR Tsai, TC Hung, BF Chen, CC Cheng, NC Chang - Tetrahedron, 2004 - Elsevier
An original alternative approach to isoquinolines based on the installation of a benzene
nucleus on a performed heterocyclic ring. Synthesis of 3, 4-dihydrobenzo [g] isoquinoline-1 …

Electrophile-driven regioselective synthesis of functionalized quinolines

S Ali, HT Zhu, XF Xia, KG Ji, YF Yang, XR Song… - Organic …, 2011 - ACS Publications
Highly substituted 3-iodoquinolines bearing different alkyl and aryl moieties can be
synthesized in moderate to excellent yields (up to 99%) by 6-endo-dig iodocyclization of 2 …