Immune control of the protozoan parasite Trypanosoma cruzi requires the activation of both
CD4+ and CD8+ T cells. We recently identified two T. cruzi trans-sialidase peptides that are …

CD8+ T cells are essential for controlling Trypanosoma cruzi infection. During Brazil strain
infection, C57BL/6 mice expand parasite-specific CD8+ T cells recognizing the dominant …

CD8+ T cells are crucial to the control of Trypanosoma cruzi infection and probably act via
multiple mechanisms, the most important being the production of interferon‐γ (IFN‐γ). In the …

During experimental infection with Trypanosoma cruzi, mice develop a strong CD8+ T cell
response focused mainly on a few immunodominant peptides encoded in trans-sialidase …

The kinetics of effector CD8+-T-cell responses to specific Trypanosoma cruzi epitopes was
investigated after challenge. Our results suggest that the delayed kinetics differs from that …

Trypanosoma cruzi infection drives the expansion of remarkably focused CD8+ T cell
responses targeting epitopes encoded by variant trans-sialidase (TS) genes. Infection of …

CD8+ T lymphocytes play a critical role in immunity to Trypanosoma cruzi. However, the
target molecules of this T cell subset have not been elucidated. In this work, we report the …

CD8+ T cells are crucial for control of a number of medically important protozoan parasites,
including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the …

Interference or competition between CD8+ T cells restricted by distinct MHC-I molecules can
be a powerful means to establish an immunodominant response. However, its importance …

MHC‐restricted CD8+ T cells are important during infection with the intracellular protozoan
parasite Trypanosoma cruzi, the causative agent of Chagas disease. Experimental studies …