Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites,
defined as two or more lesions within one to two helical turns of DNA by passage of a single …

A clustered DNA lesion, also known as a multiply damaged site, is defined as≥ 2 damages
in the DNA within 1–2 helical turns. Only ionizing radiation and certain chemicals introduce …

Cells manage to survive, thrive, and divide with high accuracy despite the constant threat of
DNA damage. Cells have evolved with several systems that efficiently repair spontaneous …

The accumulated evidence in the literature indicates that a cluster of two or more lesions
within one or two helical turns of the DNA is more challenging to repair than individual …

Ionizing radiation induces both isolated DNA lesions and clustered damages multiple
closely spaced lesions (strand breaks, oxidized purines, oxidized pyrimidines, or abasic …

DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The …

The faithful repair of DNA double-strand breaks (DSBs) is probably one of the most critical
tasks for a cell in order to maintain its genomic integrity since these lesions may lead to …

Abstract Hada, M. and Sutherland, BM Spectrum of Complex DNA Damages Depends on
the Incident Radiation. Radiat. Res. 165, 223–230 (2006). Ionizing radiation induces …

Ionising radiation induces a variety of chemical modifications to DNA, ranging from simple,
isolated lesions to clustered DNA damage, in which two or more lesions are formed within a …