Integrity and ethical issues play a role throughout all phases of clinical research. First,
policies and decisions that determine the research agenda, prioritizing some topics above …

Abstract Is Institutional Review Board (IRB) approval and a rigorous informed consent
process enough? It is our view that this is no longer the case. Conventional research ethics …

The ethical analysis of research with human subjects has been greatly developed over the
last 20 years, with input from researchers and statisticians as well as philosophers. That all …

Clinical research has resulted in significant benefits for society, yet continues to pose
profound ethical questions. This chapter briefly describes: five overlapping but distinct eras …

Ethical guidelines for conducting clinical trials have historically been based on a perceived
therapeutic obligation to treat and benefit the patient-participants. The origins of this ethical …

Why the ethical justification of randomized clinical trials is a scientific question -
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Clinical research attempts to address a relatively straightforward, and important challenge:
how do we determine whether one medical intervention is better than another, whether it …

Clinical research has at least three problematic features: it tends to be redundant, secretive,
and isolated. Research with these features not only wastes resources and causes harm, it …

In her critique of research ethics, Rosamond Rhodes identifies at least three aspects of the
field that she believes require significant rethinking and reform (Rhodes 2005). Each is part …

The paper by Claudot et al. 1 raises an important issue for today's epidemiological research:
the disparity of norms and procedures for ethical review prevailing in different countries …