KAT8 beyond Acetylation: A Survey of Its Epigenetic Regulation, Genetic Variability, and Implications for Human Health
L Yoo, D Mendoza, AJ Richard, JM Stephens - Genes, 2024 - mdpi.com
Lysine acetyltransferase 8, also known as KAT8, is an enzyme involved in epigenetic
regulation, primarily recognized for its ability to modulate histone acetylation. This review …
regulation, primarily recognized for its ability to modulate histone acetylation. This review …
Neurodevelopmental functions and activities of the KAT3 class of lysine acetyltransferases
The human lysine acetyltransferases KAT3A (CREBBP) and KAT3B (EP300) are essential
enzymes in gene regulation in the nucleus. Their ubiquitous expression in metazoan cell …
enzymes in gene regulation in the nucleus. Their ubiquitous expression in metazoan cell …
Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability
L Li, M Ghorbani, M Weisz-Hubshman… - The Journal of …, 2020 - Am Soc Clin Investig
Epigenetic integrity is critical for many eukaryotic cellular processes. An important question
is how different epigenetic regulators control development and influence disease. Lysine …
is how different epigenetic regulators control development and influence disease. Lysine …
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology
N Wiesel-Motiuk, YG Assaraf - Drug Resistance Updates, 2020 - Elsevier
Histone modifications and more specifically ε-lysine acylations are key epigenetic regulators
that control chromatin structure and gene transcription, thereby impacting on various …
that control chromatin structure and gene transcription, thereby impacting on various …
Clinical features and underlying mechanisms of KAT6B disease in a Chinese boy
X Sun, X Luo, L Lin, S Wang, C Wang… - … Genetics & Genomic …, 2023 - Wiley Online Library
Abstract Background Lysine acetyltransferase 6B (KAT6B) encodes a highly conserved
histone acetyltransferase that regulates the expression of multiple genes and is essential for …
histone acetyltransferase that regulates the expression of multiple genes and is essential for …
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
LM Weber, Y Jia, B Stielow… - Nucleic acids …, 2023 - academic.oup.com
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin
regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in …
regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in …
Regulation of KAT6 acetyltransferases and their roles in cell cycle progression, stem cell maintenance, and human disease
F Huang, SM Abmayr, JL Workman - Molecular and cellular biology, 2016 - Taylor & Francis
The lysine acetyltransferase 6 (KAT6) histone acetyltransferase (HAT) complexes are highly
conserved from yeast to higher organisms. They acetylate histone H3 and other nonhistone …
conserved from yeast to higher organisms. They acetylate histone H3 and other nonhistone …
KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain
MI Bergamasco, W Abeysekera… - Life Science …, 2025 - life-science-alliance.org
Heterozygous mutations in the histone lysine acetyltransferase gene KAT6B
(MYST4/MORF/QKF) underlie neurodevelopmental disorders, but the mechanistic roles of …
(MYST4/MORF/QKF) underlie neurodevelopmental disorders, but the mechanistic roles of …
De novo KAT5 variants cause a syndrome with recognizable facial dysmorphisms, cerebellar atrophy, sleep disturbance, and epilepsy
KAT5 encodes an essential lysine acetyltransferase, previously called TIP60, which is
involved in regulating gene expression, DNA repair, chromatin remodeling, apoptosis, and …
involved in regulating gene expression, DNA repair, chromatin remodeling, apoptosis, and …
Hotspot Cancer Mutation Impairs KAT8-mediated Nucleosomal Histone Acetylation
KAT8 is an evolutionarily conserved lysine acetyltransferase that catalyzes histone
acetylation at H4K16 or H4K5 and H4K8 through distinct protein complexes. It plays a …
acetylation at H4K16 or H4K5 and H4K8 through distinct protein complexes. It plays a …