Finite element modeling of brain tumor mass-effect from 3D medical images

A Mohamed, C Davatzikos - … Conference, Palm Springs, CA, USA, October …, 2005 - Springer
Motivated by the need for methods to aid the deformable registration of brain tumor images,
we present a three-dimensional (3D) mechanical model for simulating large non-linear …

A comparative study of biomechanical simulators in deformable registration of brain tumor images

EI Zacharaki, CS Hogea, G Biros… - IEEE Transactions on …, 2008 - ieeexplore.ieee.org
Simulating the brain tissue deformation caused by tumor growth has been found to aid the
deformable registration of brain tumor images. In this paper, we evaluate the impact that …

A biomechanical model of soft tissue deformation, with applications to non-rigid registration of brain images with tumor pathology

SK Kyriacou, C Davatzikos - … Conference Cambridge, MA, USA, October 11 …, 1998 - Springer
The finite element method is applied to the biomechanics of brain tissue deformation.
Emphasis is given to the deformations induced by the growth of tumors, and to the …

Nonlinear elastic registration of brain images with tumor pathology using a biomechanical model [MRI]

SK Kyriacou, C Davatzikos, SJ Zinreich… - IEEE transactions on …, 1999 - ieeexplore.ieee.org
A biomechanical model of the brain is presented, using a finite-element formulation.
Emphasis is given to the modeling of the soft-tissue deformations induced by the growth of …

Model-updated image-guided neurosurgery: Preliminary analysis using intraoperative MR

MI Miga, A Staubert, KD Paulsen, FE Kennedy… - … Image Computing and …, 2000 - Springer
In this paper, initial clinical data from an intraoperative MR system are compared to
calculations made by a three-dimensional finite element model of brain deformation. The …

Deformable registration of brain tumor images via a statistical model of tumor-induced deformation

A Mohamed, EI Zacharaki, D Shen, C Davatzikos - Medical image analysis, 2006 - Elsevier
An approach to the deformable registration of three-dimensional brain tumor images to a
normal brain atlas is presented. The approach involves the integration of three components …

A robust framework for soft tissue simulations with application to modeling brain tumor mass effect in 3D MR images

C Hogea, G Biros, F Abraham… - Physics in Medicine & …, 2007 - iopscience.iop.org
We present a framework for black-box and flexible simulation of soft tissue deformation for
medical imaging and surgical planning applications. Our main motivation in the present …

Brain shift computation using a fully nonlinear biomechanical model

A Wittek, R Kikinis, SK Warfield, K Miller - … Springs, CA, USA, October 26-29 …, 2005 - Springer
In the present study, fully nonlinear (ie accounting for both geometric and material
nonlinearities) patient specific finite element brain model was applied to predict deformation …

Patient-specific model of brain deformation: Application to medical image registration

A Wittek, K Miller, R Kikinis, SK Warfield - Journal of biomechanics, 2007 - Elsevier
This contribution presents finite element computation of the deformation field within the brain
during craniotomy-induced brain shift. The results were used to illustrate the capabilities of …

Patient-specific non-linear finite element modelling for predicting soft organ deformation in real-time; Application to non-rigid neuroimage registration

A Wittek, G Joldes, M Couton, SK Warfield… - Progress in biophysics …, 2010 - Elsevier
Long computation times of non-linear (ie accounting for geometric and material non-
linearity) biomechanical models have been regarded as one of the key factors preventing …