Mechanisms of mitochondrial dysfunction in Alzheimer's disease

C Cadonic, MG Sabbir, BC Albensi - Molecular neurobiology, 2016 - Springer
Mitochondria are the primary source for energy generation in the cell, which manifests itself
in the form of the adenosine triphosphate (ATP). Nicotinamide dinucleotide (NADH) …

Mechanisms of mitochondrial malfunction in Alzheimer's disease: new therapeutic hope

SU Nabi, A Khan, EM Siddiqui… - Oxidative medicine …, 2022 - Wiley Online Library
Mitochondria play a critical role in neuron viability or death as it regulates energy
metabolism and cell death pathways. They are essential for cellular energy metabolism …

Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease

SN Rai, C Singh, A Singh, MP Singh, BK Singh - Molecular Neurobiology, 2020 - Springer
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …

Molecular basis of Alzheimer's disease: focus on mitochondria

D Oliver, PH Reddy - Journal of Alzheimer's Disease, 2019 - content.iospress.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by
memory loss and multiple cognitive impairments. With the increased aging population, AD is …

Mitochondrial dysfunction contributes to the pathogenesis of Alzheimer's disease

FA Cabezas-Opazo, K Vergara-Pulgar… - Oxidative medicine …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of people
worldwide. Currently, there is no effective treatment for AD, which indicates the necessity to …

The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer's disease and Parkinson's disease

G Monzio Compagnoni, A Di Fonzo, S Corti… - Molecular …, 2020 - Springer
Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Mitochondria and mitochondrial cascades in Alzheimer's disease

RH Swerdlow - Journal of Alzheimer's Disease, 2018 - content.iospress.com
Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances

W Wang, F Zhao, X Ma, G Perry, X Zhu - Molecular neurodegeneration, 2020 - Springer
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Mitochondrial dysfunction—a pharmacological target in Alzheimer's disease

GP Eckert, K Renner, SH Eckert, J Eckmann… - Molecular …, 2012 - Springer
Increasing evidences suggest that mitochondrial dysfunction plays an important role in the
pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD) …

The role of mitochondrial dysfunction in Alzheimer's disease: a potential pathway to treatment

AB Reiss, S Ahmed, C Dayaramani, AD Glass… - Experimental …, 2022 - Elsevier
Background Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and
is characterized by progressive memory loss and cognitive impairment. Our understanding …