[HTML][HTML] Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

J Liu, R Cao, M Xu, X Wang, H Zhang, H Hu, Y Li, Z Hu… - Cell discovery, 2020 - nature.com
Dear Editor, The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat …

[HTML][HTML] The rise and fall of chloroquine/hydroxychloroquine as compassionate therapy of COVID-19

E Manivannan, C Karthikeyan… - Frontiers in …, 2021 - frontiersin.org
The emergence and rapid spread of novel coronavirus disease (COVID-19) has posed a
serious challenge to global public health in 2020. The speed of this viral spread together …

A pharmacological perspective of chloroquine in SARS-CoV-2 infection: An old drug for the fight against a new coronavirus?

TJ Oscanoa, R Romero-Ortuno, A Carvajal… - International journal of …, 2020 - Elsevier
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is having serious consequences on …

Treating COVID-19 with hydroxychloroquine (TEACH): a multicenter, double-blind randomized controlled trial in hospitalized patients

RJ Ulrich, AB Troxel, E Carmody… - Open forum …, 2020 - academic.oup.com
Background Effective therapies to combat coronavirus 2019 (COVID-19) are urgently
needed. Hydroxychloroquine (HCQ) has in vitro antiviral activity against severe acute …

[HTML][HTML] Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

SGP Funnell, WE Dowling, C Muñoz-Fontela… - Nature …, 2020 - nature.com
There is an urgent need for drugs, therapies and vaccines to be available to protect the
human population against COVID-19. One of the first approaches taken in the COVID-19 …

Assessing the efficacy and safety of hydroxychloroquine as outpatient treatment of COVID-19: a randomized controlled trial

I Schwartz, ME Boesen, G Cerchiaro… - … Open Access Journal, 2021 - cmajopen.ca
Background: Identification of therapies to prevent severe COVID-19 remains a priority. We
sought to determine whether hydroxychloroquine treatment for outpatients with SARS-CoV-2 …

[HTML][HTML] Chloroquine and hydroxychloroquine in the treatment of COVID-19: the never-ending story

A Gasmi, M Peana, S Noor, R Lysiuk, A Menzel… - Applied microbiology …, 2021 - Springer
The anti-malarial drugs chloroquine (CQ) and hydroxychloroquine (HCQ) have been
suggested as promising agents against the new coronavirus SARS-CoV-2 that induces …

Hydroxychloroquine and chloroquine for treatment of SARS-CoV-2 (COVID-19)

KA Pastick, EC Okafor, F Wang… - Open forum …, 2020 - academic.oup.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly emerging viral
infection causing coronavirus disease 2019 (COVID-19). Hydroxychloroquine and …

Compassionate use of hydroxychloroquine in clinical practice for patients with mild to severe Covid-19 in a French university hospital

O Paccoud, F Tubach, A Baptiste… - Clinical Infectious …, 2021 - academic.oup.com
Background Data from nonrandomized studies have suggested that hydroxychloroquine
could be an effective therapeutic agent against coronavirus disease 2019 (COVID-19) …

[HTML][HTML] Clinical efficacy of chloroquine derivatives in COVID-19 infection: comparative meta-analysis between the big data and the real world

M Million, P Gautret, P Colson, Y Roussel… - New Microbes and New …, 2020 - Elsevier
In the context of the current coronavirus disease 2019 (COVID-19) pandemic, we conducted
a meta-analysis on the effects of chloroquine derivatives in patients, based on unpublished …