A systematic review and meta-analysis on chloroquine and hydroxychloroquine as monotherapy or combined with azithromycin in COVID-19 treatment

RM Ghazy, A Almaghraby, R Shaaban, A Kamal… - Scientific reports, 2020 - nature.com
Many recent studies have investigated the role of either Chloroquine (CQ) or
Hydroxychloroquine (HCQ) alone or in combination with azithromycin (AZM) in the …

Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial

W Tang, Z Cao, M Han, Z Wang, J Chen, W Sun, Y Wu… - bmj, 2020 - bmj.com
Objective To assess the efficacy and safety of hydroxychloroquine plus standard of care
compared with standard of care alone in adults with coronavirus disease 2019 (covid-19) …

Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19

M Huang, M Li, F Xiao, P Pang, J Liang… - National Science …, 2020 - academic.oup.com
Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has
been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed to …

An open-label randomized controlled trial evaluating the efficacy of chloroquine/hydroxychloroquine in severe COVID-19 patients

Á Réa-Neto, RS Bernardelli, BMD Câmara, FB Reese… - Scientific reports, 2021 - nature.com
Despite several studies designed to evaluate the efficacy of chloroquine and
hydroxychloroquine in the treatment of coronavirus disease 2019 (COVID-19), there is still …

A multicenter, randomized, open-label, controlled trial to evaluate the efficacy and tolerability of hydroxychloroquine and a retrospective study in adult patients with …

CP Chen, YC Lin, TC Chen, TY Tseng, HL Wong… - PloS one, 2020 - journals.plos.org
Objective In this study, we evaluated the efficacy of hydroxychloroquine (HCQ) against
coronavirus disease 2019 (COVID-19) via a randomized controlled trial (RCT) and a …

Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19

B Singh, H Ryan, T Kredo, M Chaplin… - Cochrane Database …, 2021 - cochranelibrary.com
Background The coronavirus disease 2019 (COVID‐19) pandemic has resulted in
substantial mortality. Some specialists proposed chloroquine (CQ) and hydroxychloroquine …

COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression

D Zhou, SM Dai, Q Tong - Journal of Antimicrobial …, 2020 - academic.oup.com
A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept
across 31 provinces in China and over 40 countries worldwide. The transition from first …

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials

C Axfors, AM Schmitt, P Janiaud, J Van't Hooft… - Nature …, 2021 - nature.com
Substantial COVID-19 research investment has been allocated to randomized clinical trials
(RCTs) on hydroxychloroquine/chloroquine, which currently face recruitment challenges or …

Efficacy of chloroquine and hydroxychloroquine for the treatment of hospitalized COVID-19 patients: a meta-analysis

J Deng, F Zhou, K Heybati, S Ali, QK Zuo, W Hou… - Future …, 2022 - Taylor & Francis
Aims: To evaluate the efficacy and safety of hydroxychloroquine/chloroquine, with or without
azithromycin, in treating hospitalized COVID-19 patients. Materials & methods: Data from …

Safety of hydroxychloroquine among outpatient clinical trial participants for COVID-19

SM Lofgren, MR Nicol, AS Bangdiwala… - Open forum …, 2020 - academic.oup.com
Background Use of hydroxychloroquine in hospitalized patients with coronavirus disease
2019 (COVID-19), especially in combination with azithromycin, has raised safety concerns …